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Altered Immune Regulation of Dendritic Cells and Enhanced Cytokine Production of T Cells in the Pathogenesis of Eosinophilic Chronic Rhinosinusitis

Authors :
Nobuo Ohta
Chiaki Masuda-Suzuki
Tomoko Takahashi
Isao Ohno
Kaori Kawakami
Yutaka Nakamura
Yusuke Kusano
Tomomitsu Miyasaka
Shiori Kitaya
Yutaka Tateda
Tasuku Kawano
Motoaki Takayanagi
Tomohiro Arikawa
Fumi Shoji
Source :
International archives of allergy and immunology. 182(6)
Publication Year :
2020

Abstract

Introduction: Eosinophilic chronic rhinosinusitis (ECRS) is a refractory chronic disease defined by recurrent nasal polyps with severe eosinophilic infiltration. This is mainly due to enhanced type 2-dominant immune responses, but the underlying mechanism is still not fully understood. Objective and Methods: In the present study, we aimed to determine the characteristics of dendritic cells (DCs) and cytokine profiles of T cells in the peripheral blood of individuals with ECRS and age- and sex-matched healthy controls (HC). Results and Conclusion: The ratios of myeloid (m)DC1s to DCs and PD-L1+ mDC1s to mDC1s were higher in ECRS patients than in HC. The proportions of plasmacytoid (p)DCs in DCs, and human leukocyte antigen-DR+ pDCs and ILT3+ pDCs in pDCs were lower in ECRS patients than in HC. In a characterization of T cells, IL-4+CD4+, IFN-γ+CD4+, IL-4+IFN-γ+CD4+, IL-4+Foxp3+CD4+, IFN-γ+Foxp3+CD4+, IFN-γ+IL-4−Foxp3−CD4+, IL-4+CD8+, IL-4+IFN-γ+CD8+, and IL-4+Foxp3+CD8+ T-cell populations were significantly higher in ECRS patients than in HC. These results suggest that the enhanced immune regulation of mDC1, diminished capacity of pDCs, and increased proportion of the T-cell phenotypes in peripheral blood might be factors in ECRS pathogenesis.

Details

ISSN :
14230097
Volume :
182
Issue :
6
Database :
OpenAIRE
Journal :
International archives of allergy and immunology
Accession number :
edsair.doi.dedup.....0cd93d4ef983bf74a9c4660b36ebc3ec