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Alteration of biliary ursodeoxycholic acid in guinea pig during early stages of cholestyramine feeding
- Source :
- Steroids. 34:705-715
- Publication Year :
- 1979
- Publisher :
- Elsevier BV, 1979.
-
Abstract
- The effects of cholestyramine feeding on biliary ursodeoxycholic acid, fecal excretion of bile acids and neutral sterols on cholesterol 7α-hydroxylase and hepatic HMG-CoA reductase were examined in the guinea pig. In the bile there was a 57% decrease in the concentration of ursodeoxycholic acid while an increase was observed in the concentration of chenodeoxycholic acid. Cholestyramine feeding for ten days resulted in a decrease in plasma cholesterol levels and an increase in both hepatic HMG-CoA reductase and cholesterol 7α-hydroxylase activities. The fecal excretion of both bile acids and neutral sterols was significantly increased.
- Subjects :
- Male
medicine.medical_specialty
Cholestyramine Resin
Guinea Pigs
Clinical Biochemistry
Reductase
Chenodeoxycholic Acid
Biochemistry
Bile Acids and Salts
Guinea pig
Feces
chemistry.chemical_compound
Endocrinology
Plasma cholesterol
Internal medicine
Chenodeoxycholic acid
medicine
Animals
Bile
Cholesterol 7-alpha-Hydroxylase
Molecular Biology
Pharmacology
Cholestyramine
biology
Cholesterol
Ursodeoxycholic Acid
Organic Chemistry
Ursodeoxycholic acid
Sterols
Liver
chemistry
Steroid Hydroxylases
HMG-CoA reductase
biology.protein
Hydroxymethylglutaryl CoA Reductases
lipids (amino acids, peptides, and proteins)
Deoxycholic Acid
medicine.drug
Subjects
Details
- ISSN :
- 0039128X
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Steroids
- Accession number :
- edsair.doi.dedup.....0ced4cf6f125c90e1d4a1a8104acc29e