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Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study
- Source :
- Applied Sciences, Vol 11, Iss 10487, p 10487 (2021), Applied Sciences, Volume 11, Issue 21
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- This pilot study aims to investigate choroidal vascular status in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD), early age-related macular degeneration (AMD), and age-matched controls. In this retrospective study, choroidal thickness (CT) was measured manually using spectral domain optical coherence tomography images of the fovea, and 500 and 1500 µm from the nasal and temporal regions in the fovea. The horizontal B-scan was imported into Fiji software. Choroidal vascularity index (CVI) and luminal and stromal areas were calculated. A total of 36 eyes from 36 patients, including 18 eyes with AOFVD and 18 eyes with CD, and 16 eyes of healthy subjects were included. CVI was significantly different among subgroups (ANOVA, p = 0.004). Eyes with AOFVD presented a higher CVI (+0.03 ± 0.01, p = 0.001) than eyes with CD and controls (p = 0.03). No differences in CVI were detected between controls and eyes with CD (p = 0.25). AOFVD eyes accounted for the greatest luminal area, particularly significant in comparison with healthy controls (+0.27 ± 0.11, p = 0.02). AOFVD eyes present a greater CVI than eyes with CD and controls. The major choroidal involvement is on the luminal component, further corroborating a possible role of the choroidal vasculature in the pathological manifestations of AOFVD disease.
- Subjects :
- choroidal thickness
adult-onset foveomacular vitelliform dystrophy
Technology
medicine.medical_specialty
genetic structures
QH301-705.5
QC1-999
Spectral domain
Vascularity
Ophthalmology
conventional drusen
medicine
General Materials Science
age-related macular degeneration
choroidal vascularity index
spectral domain optical coherence tomography
Biology (General)
QD1-999
Instrumentation
Pathological
Fluid Flow and Transfer Processes
business.industry
Physics
Process Chemistry and Technology
General Engineering
Healthy subjects
Dystrophy
Macular degeneration
Engineering (General). Civil engineering (General)
medicine.disease
eye diseases
Computer Science Applications
Chemistry
Temporal Regions
sense organs
TA1-2040
medicine.symptom
business
Subjects
Details
- ISSN :
- 20763417
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Applied Sciences
- Accession number :
- edsair.doi.dedup.....0cf07becdd196a2c33bda76e84ed7ec3
- Full Text :
- https://doi.org/10.3390/app112110487