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Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study

Authors :
Serena Fragiotta
Gianluca Scuderi
Chiara Ciacimino
Solmaz Abdolrahimzadeh
Mariachiara Di Pippo
Source :
Applied Sciences, Vol 11, Iss 10487, p 10487 (2021), Applied Sciences, Volume 11, Issue 21
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

This pilot study aims to investigate choroidal vascular status in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD), early age-related macular degeneration (AMD), and age-matched controls. In this retrospective study, choroidal thickness (CT) was measured manually using spectral domain optical coherence tomography images of the fovea, and 500 and 1500 µm from the nasal and temporal regions in the fovea. The horizontal B-scan was imported into Fiji software. Choroidal vascularity index (CVI) and luminal and stromal areas were calculated. A total of 36 eyes from 36 patients, including 18 eyes with AOFVD and 18 eyes with CD, and 16 eyes of healthy subjects were included. CVI was significantly different among subgroups (ANOVA, p = 0.004). Eyes with AOFVD presented a higher CVI (+0.03 ± 0.01, p = 0.001) than eyes with CD and controls (p = 0.03). No differences in CVI were detected between controls and eyes with CD (p = 0.25). AOFVD eyes accounted for the greatest luminal area, particularly significant in comparison with healthy controls (+0.27 ± 0.11, p = 0.02). AOFVD eyes present a greater CVI than eyes with CD and controls. The major choroidal involvement is on the luminal component, further corroborating a possible role of the choroidal vasculature in the pathological manifestations of AOFVD disease.

Details

ISSN :
20763417
Volume :
11
Database :
OpenAIRE
Journal :
Applied Sciences
Accession number :
edsair.doi.dedup.....0cf07becdd196a2c33bda76e84ed7ec3
Full Text :
https://doi.org/10.3390/app112110487