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Resveratrol modulates autophagy and NF-κB activity in a murine model for treating non-alcoholic fatty liver disease
- Source :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 63
- Publication Year :
- 2013
-
Abstract
- In this study, we aimed to investigate the therapeutic effects and involved mechanisms of resveratrol on an established non-alcoholic fatty liver disease (NAFLD) murine model. Wild-type and autophagic mediator ULK1 heterozygous knockout mice were induced to have NAFLD by high-fat diet for 8weeks. After that, resveratrol treatment was applied with the high-fat diet feeding for another 4weeks. Typical features of NAFLD, including histological changes, fibrosis, insulin resistance, oxidative status, and inflammation were characterized. After-treatment with resveratrol showed ameliorative effects on all measured features of NAFLD, from histology, insulin resistance, glucose tolerance to oxidative stress and inflammation. resveratrol treatment also reduced the activity of nuclear factor-κB (NF-κB) through the restoration of its inhibitor IκBα. Partial inhibition of ULK1 expression impaired the ameliorative effects of resveratrol on hepatic histology, fibrosis, oxidative status, inflammation, and NF-κB activity. In conclusion, resveratrol improved NAFLD-caused hepatic injury partially through regulating autophagic and IκBα-NF-κB pathways.
- Subjects :
- Male
medicine.medical_specialty
Resveratrol
Biology
Toxicology
medicine.disease_cause
Diet, High-Fat
Polymerase Chain Reaction
chemistry.chemical_compound
Mice
Insulin resistance
AMP-activated protein kinase
Fibrosis
Internal medicine
Stilbenes
medicine
Autophagy
Animals
DNA Primers
Inflammation
Fatty liver
NF-kappa B
General Medicine
medicine.disease
Fatty Liver
Mice, Inbred C57BL
IκBα
Disease Models, Animal
Oxidative Stress
Endocrinology
chemistry
biology.protein
Insulin Resistance
Oxidative stress
Food Science
Subjects
Details
- ISSN :
- 18736351
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Accession number :
- edsair.doi.dedup.....0d069178afc0fe35d59c5a54ed573baf