Back to Search
Start Over
Reward signalling in brainstem nuclei under fluctuating blood glucose
- Source :
- PLoS ONE, Vol 16, Iss 4, p e0243899 (2021), Morville, T, Madsen, K H, Siebner, H R & Hulme, O J 2021, ' Reward signalling in brainstem nuclei under fluctuating blood glucose ', PLOS ONE, vol. 16, no. 4, e0243899 . https://doi.org/10.1371/journal.pone.0243899, PLoS ONE, Morville, T, Madsen, K H, Siebner, H R & Hulme, O J 2021, ' Reward signalling in brainstem nuclei under fluctuating blood glucose ', PLoS ONE, vol. 16, no. 4, e0243899 . https://doi.org/10.1371/journal.pone.0243899
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Phasic dopamine release from mid-brain dopaminergic neurons is thought to signal errors of reward prediction (RPE). If reward maximisation is to maintain homeostasis, then the value of primary rewards should be coupled to the homeostatic errors they remediate. This leads to the prediction that RPE signals should be configured as a function of homeostatic state and thus diminish with the attenuation of homeostatic error. To test this hypothesis, we collected a large volume of functional MRI data from five human volunteers on four separate days. After fasting for 12 hours, subjects consumed preloads that differed in glucose concentration. Participants then underwent a Pavlovian cue-conditioning paradigm in which the colour of a fixation-cross was stochastically associated with the delivery of water or glucose via a gustometer. This design afforded computation of RPE separately for better- and worse-than expected outcomes during ascending and descending trajectories of serum glucose fluctuations. In the parabrachial nuclei, regional activity coding positive RPEs scaled positively with serum glucose for both ascending and descending glucose levels. The ventral tegmental area and substantia nigra became more sensitive to negative RPEs when glucose levels were ascending. Together, the results suggest that RPE signals in key brainstem structures are modulated by homeostatic trajectories of naturally occurring glycaemic flux, revealing a tight interplay between homeostatic state and the neural encoding of primary reward in the human brain.
- Subjects :
- Blood Glucose
Male
0301 basic medicine
Physiology
Dopamine
Social Sciences
Biochemistry
Diagnostic Radiology
Catecholamines
Learning and Memory
0302 clinical medicine
Cell Signaling
Animal Cells
Functional Magnetic Resonance Imaging
Medicine and Health Sciences
Homeostasis
Psychology
Amines
Neurons
Brain Mapping
Multidisciplinary
medicine.diagnostic_test
Organic Compounds
Radiology and Imaging
Monosaccharides
Dopaminergic
Neurochemistry
Neurotransmitters
Human brain
Parabrachial Nucleus
Magnetic Resonance Imaging
Substantia Nigra
Ventral tegmental area
Chemistry
medicine.anatomical_structure
Physical Sciences
Medicine
Female
Brainstem
Cellular Types
Neurochemicals
Research Article
Signal Transduction
medicine.drug
Adult
Biogenic Amines
Imaging Techniques
Science
Carbohydrates
Neuroimaging
Substantia nigra
Biology
Glucose Signaling
Research and Analysis Methods
03 medical and health sciences
Reward
Diagnostic Medicine
medicine
Humans
Learning
Ventral Tegmental Area
Organic Chemistry
Chemical Compounds
Cognitive Psychology
Biology and Life Sciences
Cell Biology
Hormones
Glucose
030104 developmental biology
Cellular Neuroscience
Cognitive Science
Physiological Processes
Functional magnetic resonance imaging
Dopaminergics
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....0d0bd0811aeb560aa1ca293c6a7733ed