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Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats
- Source :
- Life sciences. 216
- Publication Year :
- 2018
-
Abstract
- The present study aimed to evaluate the renoprotective effects of chelerythrine (CHE), a protein kinase C inhibitor, on neonatal rats after partial unilateral ureteral obstruction (UUO) surgery. New born Sprague Dawley rats were subjected to partial UUO 48 h after birth and received a daily intraperitoneal injection of 5 mg/kg CHE. At 21-day age, the rats were scarified and the kidneys were collected for analysis. Results showed that CHE treatment significantly increased kidney weight and restored renal function in the obstructed kidney. Histological examination demonstrated that CHE attenuated renal injury by reducing renal parenchymal loss and preventing glomerular and tubular degeneration. In addition, CHE inhibited partial UUO-induced upregulated kidney injury molecule-1 expression and apoptosis and renal fibrosis. Moreover, as a PKC inhibitor, CHE significantly inhibited PKCĪ± and PKCĪ² membrane translocation. This action may be associated with its effects of anti-apoptosis and anti-fibrosis and contribute to the renoprotection. This short-term study suggests that CHE is beneficial for obstructive nephropathy in neonatal rats and provides foundation for further studies to reveal the long-term effects of CHE on obstructive nephropathy in children and infants.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
Intraperitoneal injection
Kidney Glomerulus
Renal function
Apoptosis
urologic and male genital diseases
Kidney
030226 pharmacology & pharmacy
General Biochemistry, Genetics and Molecular Biology
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Fibrosis
Internal medicine
medicine
Renal fibrosis
Animals
General Pharmacology, Toxicology and Pharmaceutics
Protein Kinase Inhibitors
Protein kinase C
Protein Kinase C
Benzophenanthridines
integumentary system
urogenital system
General Medicine
medicine.disease
Obstructive Nephropathy
Rats
Disease Models, Animal
030104 developmental biology
Endocrinology
Chelerythrine
medicine.anatomical_structure
Kidney Tubules
chemistry
Animals, Newborn
Kidney Diseases
Ureteral Obstruction
Subjects
Details
- ISSN :
- 18790631
- Volume :
- 216
- Database :
- OpenAIRE
- Journal :
- Life sciences
- Accession number :
- edsair.doi.dedup.....0d19110ec6e4c3ea74cb36857cd6e265