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Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test
- Source :
- Terstege, D J, MacDonald, D S & Tasker, R A 2021, ' Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test ', Acta Neuropsychiatrica, vol. 33, no. 3, pp. 141-147 . https://doi.org/10.1017/neu.2021.2
- Publication Year :
- 2021
-
Abstract
- Objective:Ginsenosides, biologically active components of the root of Panax ginseng, have been reported to have therapeutic benefits in a number of disease states including psychiatric conditions such as major depressive disorder. Our objective was to determine if a standardised commercial ginseng extract, G115®, could reduce the signs of behavioural despair commonly observed in animal models of depression either alone or in combination with the selective serotonin reuptake inhibitor (SSRI) fluoxetine.Methods:Male Sprague-Dawley (SD) rats (N = 51) were divided into four groups: vehicle control, G115® ginseng root extract, fluoxetine and fluoxetine plus G115®. Rats were trained to voluntarily consume treatments twice daily for 14 days and were then tested in an open field (OF), elevated plus maze (EPM) and forced swim test (FST). Post-mortem hippocampal and prefrontal cortex tissue was analysed for expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) by western blot.Results:One-way Analysis of Variance revealed no significant group differences in the OF or plus-maze performance on any variable examined. In the FST, fluoxetine significantly reduced immobility time and increased latency to immobility. The effects of fluoxetine were further significantly potentiated by co-administration of G115®. Post-mortem tissue analysis revealed significant group differences in BDNF expression in the left hippocampus and left prefrontal cortex without any accompanying changes in TrkB expression.Conclusions:We conclude that oral G115® significantly potentiates the antidepressant-like effect of fluoxetine in the FST in the absence of potentially confounding effects on locomotion and anxiety.
- Subjects :
- Male
Elevated plus maze
Ginsenosides
Serotonin reuptake inhibitor
Panax
Prefrontal Cortex
Tropomyosin receptor kinase B
Pharmacology
Anxiety
Hippocampus
Open field
Elevated Plus Maze Test
Rats, Sprague-Dawley
03 medical and health sciences
Ginseng
0302 clinical medicine
Animal models of depression
Fluoxetine
Medicine
Animals
Receptor, trkB
Biological Psychiatry
Swimming
Depressive Disorder, Major
Behavior, Animal
business.industry
Plant Extracts
Brain-Derived Neurotrophic Factor
030227 psychiatry
Psychiatry and Mental health
Disease Models, Animal
Drug Therapy, Combination
Autopsy
business
030217 neurology & neurosurgery
Selective Serotonin Reuptake Inhibitors
medicine.drug
Behavioural despair test
Subjects
Details
- Language :
- English
- ISSN :
- 09242708
- Database :
- OpenAIRE
- Journal :
- Terstege, D J, MacDonald, D S & Tasker, R A 2021, ' Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test ', Acta Neuropsychiatrica, vol. 33, no. 3, pp. 141-147 . https://doi.org/10.1017/neu.2021.2
- Accession number :
- edsair.doi.dedup.....0d271dc5277a3bfed6d83c6d10f1aceb