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Eczema and atopy in early childhood: low IgA plasma cell counts in the jejunal mucosa
- Source :
- Archives of Disease in Childhood. 56:939-942
- Publication Year :
- 1981
- Publisher :
- BMJ, 1981.
-
Abstract
- Twenty-one children aged between 2 and 54 months, 14 with eczema and 7 with allergies in first-degree relatives, were referred for diagnostic jejunal mucosal biopsy for a variety of symptoms. A partial villous atrophy was found in 19 of the 21 biopsies obtained; the other 2 were normal. We report a highly significant (P less than 0.0001) lower IgA cell count in biopsies with partial villous atrophy compared with the results of our previous study of IgA and IgM plasma cells in the mucosal biopsies in children without eczema or a history of atopy matched for age and histological appearances. The IgM cell count was also lower.
- Subjects :
- Male
Immunoglobulin A
Pathology
medicine.medical_specialty
Allergy
Eczema
Plasma cell
Jejunum
Atopy
Atrophy
Intestinal mucosa
Hypersensitivity
medicine
Humans
Intestinal Mucosa
Jejunal mucosa
biology
business.industry
Infant
medicine.disease
medicine.anatomical_structure
Child, Preschool
Pediatrics, Perinatology and Child Health
biology.protein
Female
business
Research Article
Subjects
Details
- ISSN :
- 14682044 and 00039888
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Archives of Disease in Childhood
- Accession number :
- edsair.doi.dedup.....0d54070fe43938ea1a2d32158a8384c4