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Complex Differential Diagnosis between Primary Breast Cancer and Breast Metastasis from EGFR-Mutated Lung Adenocarcinoma: Case Report and Literature Review
- Source :
- Current Oncology, Vol 28, Iss 292, Pp 3384-3392 (2021), Current Oncology
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- We present a case of a woman with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma who received gefitinib for 2 years and obtained a partial response. The patient then developed liver metastasis and a breast lesion, displaying high estrogen receptor (ER) expression and harboring the same EGFR mutation. From the radiological studies, it was not possible to make a differential diagnosis between primary breast cancer and breast metastasis from lung cancer. After the removal of the breast nodule, thanks to the clinical history, radiology, and above all, molecular and immunohistochemical investigations, a diagnosis of breast metastasis from lung adenocarcinoma was made. This case emphasizes the importance of a comprehensive clinical, pathological, and molecular analysis in the differential diagnosis between primary breast cancer and metastases from extramammary tumor to guide adequate treatment decision making.
- Subjects :
- Oncology
medicine.medical_specialty
breast metastasis
Estrogen receptor
Adenocarcinoma of Lung
Breast Neoplasms
Case Report
lung neoplasms
Metastasis
Diagnosis, Differential
Gefitinib
Internal medicine
Medicine
Humans
Epidermal growth factor receptor
Lung cancer
skin and connective tissue diseases
RC254-282
biology
business.industry
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
ErbB Receptors
Mutation
biology.protein
Adenocarcinoma
Immunohistochemistry
Female
Differential diagnosis
business
EGFR-mutated lung adenocarcinoma
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 11980052 and 17187729
- Volume :
- 28
- Issue :
- 292
- Database :
- OpenAIRE
- Journal :
- Current Oncology
- Accession number :
- edsair.doi.dedup.....0d55b9dc8dc2a8f6585fc38e35758c62