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Complex Differential Diagnosis between Primary Breast Cancer and Breast Metastasis from EGFR-Mutated Lung Adenocarcinoma: Case Report and Literature Review

Authors :
Filippo de Marinis
Francesca Porta
Elena Guerini-Rocco
Carmine Valenza
Giuseppe Curigliano
Chiara Catania
Alessandra Rappa
Massimo Barberis
Giuseppe Viale
Source :
Current Oncology, Vol 28, Iss 292, Pp 3384-3392 (2021), Current Oncology
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

We present a case of a woman with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma who received gefitinib for 2 years and obtained a partial response. The patient then developed liver metastasis and a breast lesion, displaying high estrogen receptor (ER) expression and harboring the same EGFR mutation. From the radiological studies, it was not possible to make a differential diagnosis between primary breast cancer and breast metastasis from lung cancer. After the removal of the breast nodule, thanks to the clinical history, radiology, and above all, molecular and immunohistochemical investigations, a diagnosis of breast metastasis from lung adenocarcinoma was made. This case emphasizes the importance of a comprehensive clinical, pathological, and molecular analysis in the differential diagnosis between primary breast cancer and metastases from extramammary tumor to guide adequate treatment decision making.

Details

Language :
English
ISSN :
11980052 and 17187729
Volume :
28
Issue :
292
Database :
OpenAIRE
Journal :
Current Oncology
Accession number :
edsair.doi.dedup.....0d55b9dc8dc2a8f6585fc38e35758c62