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RNA polymerase I subunit 12 plays opposite roles in cell proliferation and migration
- Source :
- Biochemical and Biophysical Research Communications. 560:112-118
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- RNA polymerase I (Pol I) is responsible for the synthesis of the majority of ribosomal RNA molecules in eukaryotes. Pol I subunit 12 (RPA12) is involved in the transcriptional termination and lipid metabolism in yeast. However, its role in human cells hasn't been investigated so far. Here, we show that RPA12 is present in the nucleolus and nucleoplasm of HeLa cells. RPA12 can act as a positive factor to regulate Pol I-mediated transcription and the proliferation of 293T and HeLa cells. Unexpectedly, RPA12 can repress HeLa cell migration, indicating that RPA12 plays opposite roles in cell proliferation and migration. This study provides a novel insight into the role of RPA12 in human cells.
- Subjects :
- 0301 basic medicine
Transcription, Genetic
Nucleolus
Biophysics
Biochemistry
03 medical and health sciences
0302 clinical medicine
Cell Movement
RNA Polymerase I
Transcription (biology)
RNA polymerase I
Humans
Molecular Biology
Cell Proliferation
Cell Nucleus
Nucleoplasm
Cell growth
Chemistry
Cell migration
Cell Biology
Ribosomal RNA
RRNA transcription
Cell biology
DNA-Binding Proteins
HEK293 Cells
030104 developmental biology
Gene Expression Regulation
030220 oncology & carcinogenesis
Cell Nucleolus
HeLa Cells
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 560
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....0d7c3fc810c4a84707dc5e48500d353c