Figures S1-S7 Tables S1,S2 from Enhancing Proteotoxic Stress in Leiomyosarcoma Cells Triggers Mitochondrial Dysfunctions, Cell Death, and Antitumor Activity in vivo

Supplementary Figure S1: Analysis of the mutational burden in sarcoma patients.Supplementary Figure S2: Characterization of 2c-induced cell death in LMS cells. Supplementary Figure S3: Dose dependent studies. Supplementary Figure S4: Sub-mitochondrial localization of the ATP-synthase-β subunit, Cytochrome c and DIABLO/SMAC. Supplementary Figure S5: STED super-resolution microscopy of mitochondria under 2c-induced proteotoxic stress. Supplementary Figure S6: Sub-mitochondrial localization of the ATP-synthase-β subunit, Cytochrome c and DIABLO/SMAC in LMS cells. Supplementary Figure S7: HSF1 expression in LMS cells. Supplementary Table S1: List of genes constituting the two 2c-signatures used in this study. Supplementary Table S2:The 2c proteotoxic stress signature