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Rhinoviruses in infancy and risk of immunoglobulin E sensitization
Rhinoviruses in infancy and risk of immunoglobulin E sensitization
- Source :
- Journal of Medical Virology, 91(8), 1470-1478. Wiley
- Publication Year :
- 2019
-
Abstract
- Previous data about the role of viruses in the development of allergic immunoglobulin E (IgE) sensitization are contradictory. The aim of this study was to determine the possible associations between exposure to different viruses (rhinovirus, enterovirus, norovirus, and parechovirus) during the first year of life and IgE sensitization. Viruses were analyzed from stool samples collected monthly from infants participating in a prospective birth cohort study. From that study, 244 IgE sensitized case children and 244 nonsensitized control children were identified based on their allergen-specific IgE antibody levels at the age of 6, 18, and 36 months. Stool samples (n = 4576) from the case and control children were screened for the presence of rhinovirus, enterovirus, norovirus, and parechovirus RNA by reverse transcription quantitative polymerase chain reaction. The study showed that rhinovirus was the most prevalent virus detected, present in 921 (20%) samples. None of the viruses were associated with IgE sensitization in the full cohort but after stratifying by sex, the number of rhinovirus positive samples was inversely associated with IgE sensitization in boys (odds ratio [OR]: 0.81; 95% confidence interval [CI]: 0.69-0.94; P = 0.006). There was also a temporal relation between rhinoviruses and IgE sensitization, as rhinovirus exposure during the first 6 months of life was associated with a reduced risk of subsequent IgE sensitization in boys (OR: 0.76; 95% CI: 0.6-0.94; P = 0.016). In conclusion, early exposure to rhinoviruses was inversely associated with IgE sensitization but this protective association was restricted to boys.
- Subjects :
- Male
Rhinovirus
viruses
atopy
Parechovirus
CHILDREN
Immunoglobulin E
medicine.disease_cause
Atopy
Allergic sensitization
Feces
0302 clinical medicine
030212 general & internal medicine
Prospective Studies
stool
Sensitization
POPULATION
1183 Plant biology, microbiology, virology
Enterovirus
education.field_of_study
biology
Age Factors
ASSOCIATION
3. Good health
Infectious Diseases
medicine.anatomical_structure
ENTEROVIRUS INFECTIONS
Child, Preschool
DISEASES
030211 gastroenterology & hepatology
Female
Disease Susceptibility
Risk
Population
virus
ta3111
03 medical and health sciences
Sex Factors
Virology
medicine
Hypersensitivity
Humans
sex
education
EARLY-CHILDHOOD
Picornaviridae Infections
business.industry
Norovirus
ta1183
Infant, Newborn
Infant
ALLERGIC SENSITIZATION
biology.organism_classification
medicine.disease
allergy
FECAL SAMPLES
biology.protein
ASTHMA
3111 Biomedicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 01466615
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Virology
- Accession number :
- edsair.doi.dedup.....0d92a8a4b6f82ce695aed678c5cff874