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Predictive values of X-chromosome inactivation patterns and clinicohematologic parameters for vascular complications in female patients with essential thrombocythemia
- Source :
- Blood. 100(5)
- Publication Year :
- 2002
-
Abstract
- Essential thrombocythemia (ET) is a heterogeneous disorder in which the clonality of hematopoiesis varies. The clinical significance of clonality status in ET remains to be determined. We used the human androgen receptor gene (HUMARA)–polymerase chain reaction assay to investigate X-chromosome inactivation patterns (XCIPs) and their value in predicting vascular complications in 89 female patients with ET. Fifty-four (68.4%) patients had a clonal pattern of XCIP, and 15 (19.0%) had a polyclonal pattern. The remaining 20 patients had either an ambiguous or a homozygous pattern of XCIP and were therefore excluded from further analysis. Patients with clonal XCIPs were older (P = .029) and were at greater risk for thrombosis (P = .007) than were those with polyclonal XCIPs. We did not find a correlation between the occurrence of hemorrhage and XCIP (P = .492). Advanced age was predictive of thrombosis and hemorrhage. Platelet count did not influence the risk for vascular complications. Hypertension was significantly correlated with thrombotic events (P = .002), whereas diabetes mellitus and hypercholesterolemia were of no predictive value. In a multivariate analysis, age was the significant predictor of thrombosis (P = .030); however, XCIPs (P = .083) and hypertension (P = .073) tended to predict thrombosis. Our results suggest that older patients who have clonal XCIPs or hypertension are at increased risk for thrombosis and should be monitored closely for this complication.
- Subjects :
- Adult
medicine.medical_specialty
Pathology
Immunology
Hemorrhage
Biochemistry
Gastroenterology
Polymerase Chain Reaction
Predictive Value of Tests
Risk Factors
Internal medicine
Diabetes mellitus
Dosage Compensation, Genetic
medicine
Humans
Platelet
Clinical significance
Risk factor
Aged
Thrombocytosis
Vascular disease
Essential thrombocythemia
business.industry
Thrombosis
Cell Biology
Hematology
Middle Aged
medicine.disease
Female
Complication
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 00064971
- Volume :
- 100
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....0dbb1900c653a6c79d5b721ac7e0757b