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BMT decreases HFD-induced weight gain associated with decreased preadipocyte number and insulin secretion
- Source :
- PLoS ONE, Vol 12, Iss 4, p e0175524 (2017), PLoS ONE, 12(4), PLoS One, 12, PLoS ONE, PLoS One, 12, 4
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- Contains fulltext : 174709.pdf (Publisher’s version ) (Open Access) Experimental bone marrow transplantation (BMT) in mice is commonly used to assess the role of immune cell-specific genes in various pathophysiological settings. The application of BMT in obesity research is hampered by the significant reduction in high-fat diet (HFD)-induced obesity. We set out to characterize metabolic tissues that may be affected by the BMT procedure and impair the HFD-induced response. Male C57BL/6 mice underwent syngeneic BMT using lethal irradiation. After a recovery period of 8 weeks they were fed a low-fat diet (LFD) or HFD for 16 weeks. HFD-induced obesity was reduced in mice after BMT as compared to HFD-fed control mice, characterized by both a reduced fat (-33%; p
- Subjects :
- Male
0301 basic medicine
Anabolism
Physiology
medicine.medical_treatment
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
Adipose tissue
lcsh:Medicine
White adipose tissue
Fatty Acids, Nonesterified
Weight Gain
Biochemistry
Fats
Eating
Feces
Mice
chemistry.chemical_compound
Endocrinology
0302 clinical medicine
Animal Cells
Adipocyte
Insulin Secretion
Medicine and Health Sciences
Adipocytes
Insulin
lcsh:Science
Diet, Fat-Restricted
Connective Tissue Cells
Bone Marrow Transplantation
2. Zero hunger
Multidisciplinary
C-Peptide
Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6]
Animal Models
Lipids
Pathophysiology
surgical procedures, operative
Physiological Parameters
Adipose Tissue
Experimental Organism Systems
Connective Tissue
Anatomy
Cellular Types
medicine.symptom
Research Article
medicine.medical_specialty
Adipose Tissue, White
Endocrine System
Mouse Models
030209 endocrinology & metabolism
Biology
Research and Analysis Methods
Diet, High-Fat
03 medical and health sciences
Exocrine Glands
Model Organisms
Internal medicine
medicine
Animals
Obesity
Pancreas
Triglycerides
Diabetic Endocrinology
Macrophages
Body Weight
lcsh:R
Biology and Life Sciences
Cell Biology
Glucose Tolerance Test
Hormones
Mice, Inbred C57BL
Biological Tissue
030104 developmental biology
chemistry
lcsh:Q
Energy Metabolism
Weight gain
Hormone
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....0dc3555d78dcddda1316e6915e3467c9