Deoxyhypusine hydrolase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and functional activity

Authors :: Anyi, V.
Pink, M.
Schmitz-Spanke, S.
Von Koschtizky, I.
Zhao, K. H.
Langer, B.
Kaiser, A.
Publication Year :: 2013
Publisher :: German Medical Science GMS Publishing House; Düsseldorf, 2013.
Abstract: Primaquine, a 4-aminoquinoline, is the only drug which cures the dormant hypnozoites of persistant liver stages from P. vivax. Increasing resistance needs the discovery of alternative pathways as drug targets to develop novel drug entities. Deoxyhypusine hydroxylase (DOHH) completes hypusine biosynthesis[for full text, please go to the a.m. URL]<br />10th Malaria Meeting

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