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Immunopathological Features of Canine Myocarditis Associated withLeishmania infantumInfection
- Source :
- BioMed Research International, BioMed Research International, Vol 2016 (2016)
- Publication Year :
- 2016
- Publisher :
- Hindawi Limited, 2016.
-
Abstract
- Myocarditis associated with infectious diseases may occur in dogs, including those caused by the protozoaNeospora caninum,Trypanosoma cruzi,Babesia canis,andHepatozoon canis. However, although cardiac disease due toLeishmaniainfection has also been documented, the immunopathological features of myocarditis have not been reported so far. The aim of this study was to examine the types of cellular infiltrates and expression of MHC classes I and II in myocardial samples obtained at necropsy from 15 dogs with an established intravitam diagnosis of visceral leishmaniasis. Pathological features of myocardium were characterized by hyaline degeneration of cardiomyocytes, necrosis, and infiltration of mononuclear inflammatory cells consisting of lymphocytes and macrophages, sometimes with perivascular pattern; fibrosis was also present in various degrees. Immunophenotyping of inflammatory cells was performed by immunohistochemistry on cryostat sections obtained from the heart of the infected dogs. The predominant leukocyte population was CD8+ with a fewer number of CD4+ cells. Many cardiomyocytes expressed MHC classes I and II on the sarcolemma.Leishmaniaamastigote forms were not detected within macrophages or any other cell of the examined samples. Our study provided evidence that myocarditis in canine visceral leishmaniasis might be related to immunological alterations associated withLeishmaniainfection.
- Subjects :
- Male
0301 basic medicine
Pathology
medicine.medical_specialty
Myocarditis
Article Subject
Immunology and Microbiology (all)
040301 veterinary sciences
Population
lcsh:Medicine
General Biochemistry, Genetics and Molecular Biology
0403 veterinary science
03 medical and health sciences
Dogs
Immunophenotyping
parasitic diseases
Leukocytes
medicine
Animals
Myocytes, Cardiac
Dog Diseases
Leishmania infantum
Trypanosoma cruzi
Amastigote
education
education.field_of_study
Biochemistry, Genetics and Molecular Biology (all)
General Immunology and Microbiology
biology
lcsh:R
Histocompatibility Antigens Class I
04 agricultural and veterinary sciences
General Medicine
biology.organism_classification
medicine.disease
Immunity, Innate
030104 developmental biology
Visceral leishmaniasis
Immunology
Babesia canis
Leishmaniasis, Visceral
Female
Research Article
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....0dd0dec52b6fcc9cbb7767d12a422d3b