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Immunopathological Features of Canine Myocarditis Associated withLeishmania infantumInfection

Authors :
Serenella Papparella
Alessandro Costagliola
Davide Ciccarelli
Iwona Otrocka-Domagała
Valeria Russo
Laura Rinaldi
Gaetano Oliva
Giuseppe Piegari
Valentina Iovane
Orlando Paciello
Costagliola, Alessandro
Piegari, Giuseppe
Otrocka Domagala, Iwona
Ciccarelli, Davide
Iovane, Valentina
Oliva, Gaetano
Russo, Valeria
Rinaldi, Laura
Papparella, Serenella
Paciello, Orlando
Source :
BioMed Research International, BioMed Research International, Vol 2016 (2016)
Publication Year :
2016
Publisher :
Hindawi Limited, 2016.

Abstract

Myocarditis associated with infectious diseases may occur in dogs, including those caused by the protozoaNeospora caninum,Trypanosoma cruzi,Babesia canis,andHepatozoon canis. However, although cardiac disease due toLeishmaniainfection has also been documented, the immunopathological features of myocarditis have not been reported so far. The aim of this study was to examine the types of cellular infiltrates and expression of MHC classes I and II in myocardial samples obtained at necropsy from 15 dogs with an established intravitam diagnosis of visceral leishmaniasis. Pathological features of myocardium were characterized by hyaline degeneration of cardiomyocytes, necrosis, and infiltration of mononuclear inflammatory cells consisting of lymphocytes and macrophages, sometimes with perivascular pattern; fibrosis was also present in various degrees. Immunophenotyping of inflammatory cells was performed by immunohistochemistry on cryostat sections obtained from the heart of the infected dogs. The predominant leukocyte population was CD8+ with a fewer number of CD4+ cells. Many cardiomyocytes expressed MHC classes I and II on the sarcolemma.Leishmaniaamastigote forms were not detected within macrophages or any other cell of the examined samples. Our study provided evidence that myocarditis in canine visceral leishmaniasis might be related to immunological alterations associated withLeishmaniainfection.

Details

ISSN :
23146141 and 23146133
Volume :
2016
Database :
OpenAIRE
Journal :
BioMed Research International
Accession number :
edsair.doi.dedup.....0dd0dec52b6fcc9cbb7767d12a422d3b