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Canstatin induces apoptosis in gastric cancer xenograft growth in mice through the mitochondrial apoptotic pathway
- Source :
- Bioscience Reports, Bioscience Reports, Vol 34, Iss 2, p e00106 (2014)
- Publication Year :
- 2014
- Publisher :
- Portland Press Ltd., 2014.
-
Abstract
- Canstatin, the non-collagenous domain of collagen type IV α-chains, belongs to a series of collagen-derived angiogenic inhibitors. In this study, the inhibitory effect of recombinant canstatin on tumour growth was investigated using a gastric cancer xenograft model. The volume and weight of tumours in mice treated with canstatin were lower than that in mice treated with PBS. Accordingly, the survival rate of these mice was significantly higher than that of mice bearing tumours treated with PBS. Moreover, valuable insight into the mechanisms mediated by canstatin was obtained.
- Subjects :
- survival rate
Collagen Type IV
lcsh:Life
lcsh:QR1-502
Biophysics
DAB, 3,3′-diaminobenzidine tetrahydrochloride
Mice, Nude
Apoptosis
Chick Embryo
Mitochondrion
Bioinformatics
Biochemistry
lcsh:Microbiology
law.invention
mitochondrial apoptotic pathway
Mice
law
Stomach Neoplasms
Cell Line, Tumor
medicine
canstatin
Animals
Humans
Molecular Biology
Survival rate
Inhibitory effect
Collagen type
Original Paper
Angiogenic inhibitors
Chemistry
gastric cancer
Cancer
HRP, horseradish peroxidase
Cell Biology
medicine.disease
VEGF, vascular endothelial growth factor
Xenograft Model Antitumor Assays
Mitochondria
lcsh:QH501-531
chick chorioallantoic membrane
Recombinant DNA
Cancer research
Heterografts
CAM, chorioallantoic membrane
Neoplasm Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 15734935 and 01448463
- Volume :
- 34
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Bioscience Reports
- Accession number :
- edsair.doi.dedup.....0df75d9bdfc95760e01441a6fe8e6acf