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Cardiac Cell Therapy: The Next (Re)Generation
- Source :
- Stem Cell Reviews and Reports, Stem Cell Reviews and Reports, Humana Press, 2011, 7 (4), pp.1018-30. ⟨10.1007/s12015-011-9252-8⟩
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Heart failure remains one of the main causes of morbidity and mortality in the Western world. Current therapies for myocardial infarction are mostly aimed at blocking the progression of the disease, preventing detrimental cardiac remodeling and potentiating the function of the surviving tissue. In the last decade, great interest has arisen from the possibility to regenerate lost tissue by using cells as a therapeutic tool. Different cell types have been tested in animal models, including bone marrow-derived cells, myoblasts, endogenous cardiac stem cells, embryonic cells and induced pluripotent stem cells. After the conflicting and often inconsistent results of the first clinical trials, a step backward needs to be performed, to understand the basic biological mechanisms underlying spontaneous and induced cardiac regeneration. Current studies aim at finding new strategies to enhance cellular homing, survival and differentiation in order to improve the overall outcome of cellular cardiomyoplasty.
- Subjects :
- Cancer Research
Pathology
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
Cellular differentiation
MESH: Myoblasts, Cardiac
heart failure
030204 cardiovascular system & hematology
Bioinformatics
0302 clinical medicine
MESH: Tissue Scaffolds
Cellular cardiomyoplasty
MESH: Animals
[INFO.INFO-BT]Computer Science [cs]/Biotechnology
MESH: Embryonic Stem Cells
Induced pluripotent stem cell
MESH: Treatment Outcome
MESH: Muscle, Skeletal
Clinical Trials as Topic
0303 health sciences
Tissue Scaffolds
MESH: Heart Diseases
MESH: Bone Marrow Cells
MESH: Regeneration
Cell Differentiation
Heart
cardiac cell therapy
stem cells
cell-survival
engraftment
3. Good health
Treatment Outcome
MESH: Cell Survival
MESH: Stem Cell Transplantation
Stem cell
Myoblasts, Cardiac
MESH: Cell Differentiation
medicine.medical_specialty
Cell type
MESH: Clinical Trials as Topic
Heart Diseases
Cell Survival
Induced Pluripotent Stem Cells
Bone Marrow Cells
MESH: Induced Pluripotent Stem Cells
03 medical and health sciences
medicine
Animals
Humans
Regeneration
Cell Lineage
Muscle, Skeletal
Embryonic Stem Cells
030304 developmental biology
MESH: Humans
business.industry
Cell Biology
MESH: Cell Lineage
medicine.disease
Embryonic stem cell
MESH: Heart
Heart failure
business
Stem Cell Transplantation
Homing (hematopoietic)
Subjects
Details
- ISSN :
- 15586804 and 15508943
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Stem Cell Reviews and Reports
- Accession number :
- edsair.doi.dedup.....0e0f0ea8c60dc3819e69ddd34fd63cb3