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Ubiquitous expression of galectin-3 mRNA in benign and malignant thyroid tumors
- Source :
- Cancer Letters. 199:69-73
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- We measured the relative expression levels of galectin-3 mRNA to beta-actin mRNA in normal thyroid tissues, thyroid tumor tissues and thyroid-derived fibroblasts. Galectin-3 mRNA was expressed ubiquitously in both benign and malignant thyroid tumors. Although a significant increase in its expression was observed in papillary carcinomas, no significant difference was observed between follicular carcinomas and adenomas. In contrast to the previous optimistic reports using immunohistochemical analysis of the galectin-3 protein expression, these results demonstrate that galectin-3 mRNA may not be a suitable target for molecular-based diagnosis of thyroid carcinomas.
- Subjects :
- Adenoma
endocrine system
Cancer Research
Pathology
medicine.medical_specialty
Transcription, Genetic
endocrine system diseases
Galectin 3
Molecular Sequence Data
Biology
Polymerase Chain Reaction
Thyroid carcinoma
Adenocarcinoma, Follicular
Gene expression
Biopsy
otorhinolaryngologic diseases
medicine
Carcinoma
Humans
RNA, Messenger
Thyroid Neoplasms
DNA Primers
Messenger RNA
Base Sequence
medicine.diagnostic_test
Thyroid
medicine.disease
Gene Expression Regulation, Neoplastic
stomatognathic diseases
medicine.anatomical_structure
Oncology
Immunohistochemistry
Endocrine gland
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 199
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....0e269c79bf94c67f542979ad3a691b55