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Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations
- Source :
- Visco, C, Wang, J, Tisi, M C, Deng, L, D'Amore, E S G, Tzankov, A, Montes-Moreno, S, Dybkær, K, Bhagat, G, Hsi, E D, van Krieken, J H, Ponzoni, M, Ferreri, A J M, Møller, M B, Piris, M A, Medeiros, L J, Xu-Monette, Z Y & Young, K H 2017, ' Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations ', British Journal of Cancer, vol. 117, no. 11, pp. 1685–1688 . https://doi.org/10.1038/bjc.2017.345, British Journal of Cancer, Visco, C, Wang, J, Tisi, M C, Deng, L, D'Amore, E S G, Tzankov, A, Montes-Moreno, S, Dybkær, K, Bhagat, G, Hsi, E D, van Krieken, J H, Ponzoni, M, Ferreri, A J M, Møller, M B, Piris, M A, Medeiros, L J, Xu-Monette, Z Y & Young, K H 2017, ' Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations ', British Journal of Cancer, vol. 117, no. 11, pp. 1685-1688 . https://doi.org/10.1038/bjc.2017.345
- Publication Year :
- 2017
-
Abstract
- BACKGROUND: The clinical presentation of patients with hepatitis C virus (HCV)-positive diffuse large B-cell lymphoma (DLBCL) is different from their HCV-negative counterparts, but the underlying molecular and pathological characteristics are largely under investigated. The virus has a role in lymphomagenesis, as witnessed by the curative potential of antiviral therapy in HCV-related low-grade B-cell lymphomas.METHODS: We performed a case-control study including 44 HCV-positive cases of de novo DLBCL, comparing them with 132 HCV-negative patients as controls (ratio 3 to 1). Cases and controls were matched for age, lactate dehydrogenase level and international prognostic index at presentation. Patients were studied by gene expression profiling for cell-of-origin determination and to perform differential expression analysis between groups, fluorescence in-situ hybridisation and immunohistochemistry for MYC, BCL2 and BCL6, TP53 mutations, and diagnostic specimens reviewed to exclude transformation from low-grade lymphoma.RESULTS: Compared to the HCV-negative controls, patients with HCV-positive de novo DLBCL had differential expression of genes that regulate innate immune response and modulate apoptotic pathways, have higher proliferative index, and lack BCL2 translocations.CONCLUSIONS: HCV-positive DLBCL have distinct molecular and pathological features compared to the HCV-negative counterparts.British Journal of Cancer advance online publication, 26 September 2017; doi:10.1038/bjc.2017.345 www.bjcancer.com.
- Subjects :
- hepatitis C virus
Male
Cancer Research
Pathology
Lymphoma
Genes, myc
Hepacivirus
medicine.disease_cause
Translocation, Genetic
0302 clinical medicine
International Prognostic Index
immune system diseases
hemic and lymphatic diseases
Hepacivirus/isolation & purification
Proto-Oncogene Proteins c-bcl-2/analysis
virus diseases
Proto-Oncogene Proteins c-bcl-6/genetics
myc
Middle Aged
BCL6
Diffuse
3. Good health
Proto-Oncogene Proteins c-bcl-2
Oncology
030220 oncology & carcinogenesis
Proto-Oncogene Proteins c-bcl-6
Female
Lymphoma, Large B-Cell, Diffuse
SIKE-1
Adult
medicine.medical_specialty
BCL2
Proliferative index
Hepatitis C virus
diffuse large B-cell lymphoma
Translocation
Biology
Virus
03 medical and health sciences
Genetic
Large B-Cell
medicine
Journal Article
Humans
Case-Control Studies
Molecular Diagnostics
medicine.disease
Genes
Hepatitis C Virus Positive
Lymphoma, Large B-Cell, Diffuse/genetics
Cancer research
Diffuse large B-cell lymphoma
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Visco, C, Wang, J, Tisi, M C, Deng, L, D'Amore, E S G, Tzankov, A, Montes-Moreno, S, Dybkær, K, Bhagat, G, Hsi, E D, van Krieken, J H, Ponzoni, M, Ferreri, A J M, Møller, M B, Piris, M A, Medeiros, L J, Xu-Monette, Z Y & Young, K H 2017, ' Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations ', British Journal of Cancer, vol. 117, no. 11, pp. 1685–1688 . https://doi.org/10.1038/bjc.2017.345, British Journal of Cancer, Visco, C, Wang, J, Tisi, M C, Deng, L, D'Amore, E S G, Tzankov, A, Montes-Moreno, S, Dybkær, K, Bhagat, G, Hsi, E D, van Krieken, J H, Ponzoni, M, Ferreri, A J M, Møller, M B, Piris, M A, Medeiros, L J, Xu-Monette, Z Y & Young, K H 2017, ' Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations ', British Journal of Cancer, vol. 117, no. 11, pp. 1685-1688 . https://doi.org/10.1038/bjc.2017.345
- Accession number :
- edsair.doi.dedup.....0e30c8710f742ab52c81d15b76a5f792