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Author Correction: Requirements for the differentiation of innate T-bet

Authors :
Kwang Soon Kim
Hidehiro Yamane
Kerry L Hilligan
Alan Sher
Naoto Ishii
Jaeu Yi
Dragana Jankovic
Difeng Fang
Takeshi Kawabe
Akihisa Kawajiri
Giorgio Trinchieri
Jinfang Zhu
Source :
Nature Communications, Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Publication Year :
2020

Abstract

CD4+ T lymphocytes consist of naïve, antigen-specific memory, and memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells exert innate-like effector function during host defense, but whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions is still unclear. Here we characterize MP lymphocytes as consisting of T-bethigh, T-betlow, and T-bet− subsets, with innate, Th1-like effector activity exclusively associated with T-bethigh cells. We further show that the latter population depends on IL-12 produced by CD8α+ type 1 dendritic cells (DC1) for its differentiation. Finally, our data demonstrate that this tonic IL-12 production requires TLR-MyD88 signaling independent of foreign agonists, and is further enhanced by CD40-CD40L interactions between DC1 and CD4+ T lymphocytes. We propose that optimal differentiation of T-bethigh MP lymphocytes at homeostasis is driven by self-recognition signals at both the DC and Tcell levels.<br />CD4+ T cells contain a T-bethigh memory-phenotype (MP) population with innate-like functions. Here the authors characterize the requirements for their differentiation at homeostasis and identify a function for IL-12 that is tonically produced by type 1 dendritic cells in an MyD88- and CD40-dependent, but foreign PAMP-independent manner.

Details

ISSN :
20411723
Volume :
11
Issue :
1
Database :
OpenAIRE
Journal :
Nature communications
Accession number :
edsair.doi.dedup.....0e3867a2dffbd1396de60e0df0183ae7