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Mild thyroid hormone excess is associated with a decreased physical function in elderly men
- Source :
- The Aging Male. 14:213-219
- Publication Year :
- 2011
- Publisher :
- Informa UK Limited, 2011.
-
Abstract
- In the adult, subclinical hyperthyroidism (Shyper) may alter skeletal muscle mass and strength. However, whether these effects are present in elderly subjects is not known. We explored the relationship between mild hyperthyroidism and physical function in a population-based sample of older persons.In a cross-sectional analysis, calf muscle cross-sectional area (CMA), handgrip strength, nerve conduction velocity (NCV), and Short Physical Performance Battery (SPPB) scores were compared between 364 euthyroid (Eut) and 28 Shyper men as well as between 502 Eut and 39 Shyper women. In a longitudinal analysis, we evaluated the relationship between baseline plasma TSH, FT3 and FT4 and the 3-year change in SPPB score in 304 men and 409 women who were euthyroid at enrolment.At the cross-sectional analysis, Shyper men, but not women, had a significantly (p = 0.02) lower SPPB score than Eut controls, although with comparable CMA, grip strength and NCV, and were more likely to have poor physical performance (odds ratio = 2.97, p0.05). Longitudinal analysis showed that in Eut men higher baseline FT4 was significantly (p = 0.02) predictive of a lower SPPB score at the 3-year follow-up.Even a modest thyroid hormone excess is associated with a reduced physical function in elderly men.
- Subjects :
- Male
medicine.medical_specialty
endocrine system diseases
Cross-sectional study
Population
Neural Conduction
Thyrotropin
Hyperthyroidism
Article
Nerve conduction velocity
Grip strength
Internal medicine
Hand strength
medicine
Humans
Euthyroid
Longitudinal Studies
Muscle, Skeletal
education
Aged
Subclinical infection
Aged, 80 and over
education.field_of_study
Triiodothyronine
Hand Strength
business.industry
Thyroxine
Cross-Sectional Studies
Endocrinology
Asymptomatic Diseases
Exercise Test
Cardiology
Female
Geriatrics and Gerontology
business
human activities
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 14730790 and 13685538
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- The Aging Male
- Accession number :
- edsair.doi.dedup.....0e597d66ce6022e3704f58045dfd0f6b