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PT/Y Mice Are Sensitive to the Inhibitory Effect of o-Aminoazotoluene on Glucocorticoid Induction of Tyrosine Aminotransferase and Its Hepatocarcinogenic Effect
- Source :
- Bulletin of experimental biology and medicine. 158(6)
- Publication Year :
- 2014
-
Abstract
- PT/Y mice used for studies of the effects of mutagens are characterized by the absence of spontaneous tumors of the liver, but often develop these tumors in response to chronic oaminoazotoluene treatment. The level of glucocorticoid induction of adaptive hepatic enzyme tyrosine aminotransferase decreases by more than 70% 24 h after acute injection of o-aminoazotoluene to these animals. These mice can serve as a model for studies of the relationship between the effect of carcinogens on the regulation of activity of adaptive hepatic enzymes and their capacity to induce the development of liver tumors.
- Subjects :
- chemistry.chemical_classification
O-Aminoazotoluene
General Medicine
Pharmacology
o-Aminoazotoluene
General Biochemistry, Genetics and Molecular Biology
Mice
Liver metabolism
Tyrosine aminotransferase
Enzyme
chemistry
Liver
Liver enzyme
medicine
Animals
Inhibitory effect
Glucocorticoids
Glucocorticoid
Carcinogen
medicine.drug
Tyrosine Transaminase
Subjects
Details
- ISSN :
- 15738221
- Volume :
- 158
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Bulletin of experimental biology and medicine
- Accession number :
- edsair.doi.dedup.....0e6a434ae7aa381c88b090475986f855