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Relationship between home blood pressure and vascular function in patients receiving antihypertensive drug treatment
- Source :
- Hypertension research : official journal of the Japanese Society of Hypertension. 42(8)
- Publication Year :
- 2018
-
Abstract
- Hypertension is associated with vascular failure, such as increased arterial stiffness, endothelial dysfunction, and vascular smooth muscle dysfunction. The purpose of this study was to investigate the relationship between out-of-office blood pressure and vascular function in patients receiving antihypertensive drugs. We assessed out-of-office blood pressure, including daytime and night-time blood pressure, by home blood pressure monitoring and performed vascular function tests, including brachial-ankle pulse wave velocity (baPWV), flow-mediated vasodilation (FMD), and nitroglycerine-induced vasodilation (NID), in 169 patients receiving antihypertensive drugs, of whom 86 (50.9%) had normotension, 23 (13.6%) had isolated nocturnal hypertension (night-time systolic blood pressure ≥120 mm Hg), 26 (15.4%) had isolated daytime hypertension (daytime systolic blood pressure ≥135 mm Hg), and 34 (20.1%) had sustained hypertension (daytime and nocturnal hypertension). baPWV was significantly higher in patients with sustained hypertension than in those without sustained hypertension (1585 ± 257 cm/s in normotension; 1687 ± 267 cm/s in isolated nocturnal hypertension; 1688 ± 313 cm/s in isolated daytime hypertension; and 1923 ± 399 cm/s in sustained hypertension; P
- Subjects :
- Adult
Male
medicine.medical_specialty
Vascular smooth muscle
Physiology
medicine.drug_class
Vasodilation
Blood Pressure
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Vascular Stiffness
Internal medicine
Internal Medicine
medicine
Humans
030212 general & internal medicine
Endothelial dysfunction
Antihypertensive drug
Pulse wave velocity
Antihypertensive Agents
Aged
Aged, 80 and over
business.industry
Odds ratio
Blood Pressure Monitoring, Ambulatory
Middle Aged
medicine.disease
Circadian Rhythm
Blood pressure
Hypertension
Cardiology
Arterial stiffness
Female
Endothelium, Vascular
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 13484214
- Volume :
- 42
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Hypertension research : official journal of the Japanese Society of Hypertension
- Accession number :
- edsair.doi.dedup.....0ea26d72e5e53e09faa2d9b9aef389bd