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Increased microfilaments in hepatocytes and biliary ductular cells in cholestatic liver diseases
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2002
- Publisher :
- Korean Academy of Medical Sciences, 2002.
-
Abstract
- To assess the extent of microfilaments in cholestatic liver diseases we examined the cytoplasmic microfilaments in intrahepatic and extrahepatic cholestasis in man by electron microscopy. Study subjects were two patients with drug-induced intrahepatic cholestasis, three patients with intrahepatic cholestasis due to viral hepatitis, four patients with extrahepatic cholestasis due to stones of the common bile duct and two patients with primary biliary cirrhosis. Two biopsied specimens from patients without clinical or histological evidence of liver disease served as noncholestatic controls. The microfilaments in hepatocytes and biliary ductular cells were significantly increased in cholestasis compared with those in non-cholestatic controls. Well developed bundles of microfilaments were noted around the pericanalicular ectoplasm and seemed to be parallel to plasma membrane of the hepatocytes in cholestasis. In cholestasis, there were increased bundles of microfilaments around the periluminal region, lateral cell wall, and nucleus of biliary ductular cells. Two patterns of microfilaments bundles (fine microfilamentous network and spindle-shaped dense or clusters of microfilaments) were associated with cholestasis. The clustered form of microfilaments also seemed to be clearly associated with intracytoplasmic vacuoles containing bile salts. In conclusion, the increase of microfilaments in hepatocytes and biliary ductular cells may be the consequence of various forms of cholestasis. Further studies are needed to clarify the functional significance of increased microfilaments in cholestasis.
- Subjects :
- medicine.medical_specialty
Biopsy
Cholestasis, Intrahepatic
Extrahepatic Cholestasis
Microfilament
Gastroenterology
Liver disease
Primary biliary cirrhosis
Cholestasis
Internal medicine
Medicine
Humans
Common bile duct
medicine.diagnostic_test
business.industry
Bile Canaliculi
General Medicine
medicine.disease
Actin cytoskeleton
Actin Cytoskeleton
Microscopy, Electron
medicine.anatomical_structure
Hepatocytes
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15986357 and 10118934
- Volume :
- 17
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....0ea3a10660f28c41dbfa95293e710739