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Genetic risk of subsequent esophageal cancer in lymphoma and breast cancer long-term survival patients: a pilot study
- Source :
- Europe PubMed Central
- Publication Year :
- 2015
- Publisher :
- Nature Publishing Group, 2015.
-
Abstract
- The occurrence of a second primary esophageal carcinoma (EC) in long-term cancer survivors may represent a late effect of previous radio-chemotherapeutic treatment. To identify the genetic factors that could increase this risk, we analyzed nine variants within ERCC1, XPD, XRCC1 and XRCC3 DNA repair pathway genes, and GSTP1, TP53 and MDM2 genes in 61 patients who received radio-chemotherapy for a prior lymphoma or breast cancer; 29 of them had a second primary EC. This cohort consists of 22 esophageal squamous cell carcinoma (ESCC) and 7 esophageal adenocarcinoma (EADC) patients. A validation cohort of 154 patients with sporadic EC was also included. The XPD Asp312Asn (rs1799793) was found to be associated with the risk of developing second primary ESCC (P=0.015). The resultant variant was also involved in the onset of sporadic ESCC (P=0.0018). To know in advance who among long-term cancer survivors have an increased risk of EC could lead to a more appropriate follow-up strategy.
- Subjects :
- 0301 basic medicine
Oncology
Male
medicine.medical_specialty
Time Factors
Esophageal Neoplasms
Lymphoma
Breast Neoplasms
Pilot Projects
Adenocarcinoma
03 medical and health sciences
GSTP1
0302 clinical medicine
Breast cancer
Risk Factors
Internal medicine
medicine
Carcinoma
Biomarkers, Tumor
Genetics
Humans
Genetic Predisposition to Disease
Survivors
Genetic Association Studies
Xeroderma Pigmentosum Group D Protein
Pharmacology
Molecular Medicine
business.industry
Late effect
Cancer
Genetic Variation
Neoplasms, Second Primary
Chemoradiotherapy
Esophageal cancer
medicine.disease
030104 developmental biology
Phenotype
Treatment Outcome
030220 oncology & carcinogenesis
Case-Control Studies
Cohort
Carcinoma, Squamous Cell
Female
Esophageal Squamous Cell Carcinoma
ERCC1
medicine.symptom
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Europe PubMed Central
- Accession number :
- edsair.doi.dedup.....0ea43a1f490809ef6baff2bc04d576bd