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Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases
- Source :
- Medicine and Science in Sports and Exercise
- Publication Year :
- 2022
- Publisher :
- Lippincott Williams & Wilkins; American College of Sports Medicine, 2022.
-
Abstract
- Supplemental digital content is available in the text.<br />Introduction Genetic pleiotropy, in which the same genes affect two or more traits, may partially explain the frequently observed associations between high physical activity (PA) and later reduced morbidity or mortality. This study investigated associations between PA polygenic risk scores (PRS) and cardiometabolic diseases among the Finnish population. Methods PRS for device-measured overall PA were adapted to a FinnGen study cohort of 218,792 individuals with genomewide genotyping and extensive digital longitudinal health register data. Associations between PA PRS and body mass index, diseases, and mortality were analyzed with linear and logistic regression models. Results A high PA PRS predicted a lower body mass index (β = −0.025 kg·m−2 per one SD change in PA PRS, SE = 0.013, P = 1.87 × 10−80). The PA PRS also predicted a lower risk for diseases that typically develop later in life or not at all among highly active individuals. A lower disease risk was systematically observed for cardiovascular diseases (odds ratio [OR] per 1 SD change in PA PRS = 0.95, P = 9.5 × 10−19) and, for example, hypertension [OR = 0.93, P = 2.7 × 10−44), type 2 diabetes (OR = 0.91, P = 4.1 × 10−42), and coronary heart disease (OR = 0.95, P = 1.2 × 10−9). Participants with high PA PRS had also lower mortality risk (OR = 0.97, P = 0.0003). Conclusions Genetically less active persons are at a higher risk of developing cardiometabolic diseases, which may partly explain the previously observed associations between low PA and higher disease and mortality risk. The same inherited physical fitness and metabolism-related mechanisms may be associated both with PA levels and with cardiometabolic disease risk.
- Subjects :
- Male
Epidemiology
Physical fitness
Type 2 diabetes
Disease
Logistic regression
TYPE 2 DIABETES
Orthopedics and Sports Medicine
315 Sport and fitness sciences
PREDICTORS
Child
kohorttitutkimus
Finland
Aged, 80 and over
sairastavuus
HERITABILITY
Genetic Pleiotropy
riskitekijät
Middle Aged
Cardiovascular Diseases
Child, Preschool
Cohort
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Female
SMOKING
geneettiset tekijät
fyysinen aktiivisuus
Adult
Genetic Markers
kuolleisuus
medicine.medical_specialty
Adolescent
Genotype
Physical Therapy, Sports Therapy and Rehabilitation
EXERCISE
pitkittäistutkimus
Lower risk
Risk Assessment
Young Adult
Metabolic Diseases
Internal medicine
Clinical Decision Rules
BENEFITS
medicine
Humans
Aged
business.industry
RISK SCORES
Cardiometabolic Risk Factors
Infant
Odds ratio
medicine.disease
GENE
BODY-MASS INDEX
Logistic Models
Case-Control Studies
Linear Models
sydän- ja verisuonitaudit
business
Body mass index
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Medicine and Science in Sports and Exercise
- Accession number :
- edsair.doi.dedup.....0eb878dc5eaf193e1df2313e017c9578