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Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women
- Source :
- European Heart Journal, 42(21), 2088-2099. Oxford University Press
- Publication Year :
- 2021
-
Abstract
- Aims To quantify the arousal burden (AB) across large cohort studies and determine its association with long-term cardiovascular (CV) and overall mortality in men and women. Methods and results We measured the AB on overnight polysomnograms of 2782 men in the Osteoporotic Fractures in Men Study (MrOS) Sleep study, 424 women in the Study of Osteoporotic Fractures (SOF) and 2221 men and 2574 women in the Sleep Heart Health Study (SHHS). During 11.2 ± 2.1 years of follow-up in MrOS, 665 men died, including 236 CV deaths. During 6.4 ± 1.6 years of follow-up in SOF, 105 women died, including 47 CV deaths. During 10.7 ± 3.1 years of follow-up in SHHS, 987 participants died, including 344 CV deaths. In women, multivariable Cox proportional hazard analysis adjusted for common confounders demonstrated that AB is associated with all-cause mortality [SOF: hazard ratio (HR) 1.58 (1.01–2.42), P = 0.038; SHHS-women: HR 1.21 (1.06–1.42), P = 0.012] and CV mortality [SOF: HR 2.17 (1.04–4.50), P = 0.037; SHHS-women: HR 1.60 (1.12–2.28), P = 0.009]. In men, the association between AB and all-cause mortality [MrOS: HR 1.11 (0.94–1.32), P = 0.261; SHHS-men: HR 1.31 (1.06–1.62), P = 0.011] and CV mortality [MrOS: HR 1.35 (1.02–1.79), P = 0.034; SHHS-men: HR 1.24 (0.86–1.79), P = 0.271] was less clear. Conclusions Nocturnal AB is associated with long-term CV and all-cause mortality in women and to a lesser extent in men.
- Subjects :
- Male
medicine.medical_specialty
Cardiovascular mortality
Polysomnography
DURATION
030204 cardiovascular system & hematology
Sleep arousal
Sleep fragmentation
03 medical and health sciences
0302 clinical medicine
Risk Factors
RISK-FACTOR
Internal medicine
APNEA
medicine
Humans
Total sleep time
030212 general & internal medicine
Sleep study
Aged
medicine.diagnostic_test
business.industry
Hazard ratio
Confounding
All-cause mortality
Cardiovascular Diseases
Female
Independent Living
FRAGMENTATION
Cardiology and Cardiovascular Medicine
business
Sleep
Arousal
Cohort study
All cause mortality
Subjects
Details
- Language :
- English
- ISSN :
- 0195668X
- Volume :
- 42
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- European Heart Journal
- Accession number :
- edsair.doi.dedup.....0ed7d9c859f5264d8d064e9756ba1108