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Coronary and Abdominal Aorta Calcification in Rheumatoid Arthritis: Relationships with Traditional Cardiovascular Risk Factors, Disease Characteristics, and Concomitant Treatments
Coronary and Abdominal Aorta Calcification in Rheumatoid Arthritis: Relationships with Traditional Cardiovascular Risk Factors, Disease Characteristics, and Concomitant Treatments
- Source :
- The Journal of Rheumatology. 41:2137-2144
- Publication Year :
- 2014
- Publisher :
- The Journal of Rheumatology, 2014.
-
Abstract
- Objective.To assess the influence of traditional cardiovascular (CV) risk factors, disease characteristics, and concomitant treatments in patients with rheumatoid arthritis (RA) on coronary artery calcification (CAC) and abdominal aorta calcification (AAC).Methods.In our cross-sectional study, 75 patients with RA were compared with 75 age-matched and sex-matched control participants. The CAC and AAC scores were measured by computed tomography in patients with no clinical evidence of coronary artery disease. The relationships between the presence or absence of CAC and AAC and traditional CV risk factors, disease characteristics, and concomitant treatments in patients with RA were assessed in a multiple logistic regression analysis.Results.The RA and control groups did not differ significantly in terms of age, sex composition, or the prevalence of traditional CV risk factors. AAC and CAC were more prevalent and severe in patients with RA than in controls. Older age (OR = 1.15, p < 0.01) and hypertension (OR = 3.77, p = 0.04) were found to be independently associated with CAC, whereas current use of methotrexate (MTX; OR = 0.12, p = 0.01) was found to be associated with the absence of CAC. Older age (OR per yr = 1.17, p < 0.001) and erosive arthritis (OR = 3.78, p = 0.03) were found to be independently associated with AAC.Conclusion.Our study demonstrates that in patients with RA, (1) CAC and AAC are more prevalent and more severe compared with age-matched and sex-matched control participants, (2) current use of MTX is a major determinant of the absence of CAC, and (3) erosive arthritis is a major determinant of AAC.
- Subjects :
- Male
medicine.medical_specialty
Cross-sectional study
Immunology
Aortic Diseases
Comorbidity
Coronary Artery Disease
Coronary Angiography
Aortography
Risk Assessment
Severity of Illness Index
Statistics, Nonparametric
Arthritis, Rheumatoid
Coronary artery disease
Age Distribution
Rheumatology
Reference Values
Internal medicine
Severity of illness
medicine
Humans
Immunology and Allergy
Aorta, Abdominal
Sex Distribution
Vascular Calcification
Aged
Analysis of Variance
business.industry
Incidence
Incidence (epidemiology)
Middle Aged
medicine.disease
Surgery
Cross-Sectional Studies
Concomitant
Rheumatoid arthritis
Female
Risk assessment
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 14992752 and 0315162X
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- The Journal of Rheumatology
- Accession number :
- edsair.doi.dedup.....0edb58454f5656f7bc2a10fe10effee5
- Full Text :
- https://doi.org/10.3899/jrheum.140239