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Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine
- Source :
- Schankin, Christoph; Maniyar, Farooq H; Seo, Youngho; Kori, Shashidar; Eller, Michael; Chou, Denise E; Blecha, Joseph; Murphy, Stephanie T; Hawkins, Randall A; Sprenger, Till; VanBrocklin, Henry F; Goadsby, Peter J (2016). Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine. Brain, 139(Pt 7), pp. 1994-2001. Oxford University Press 10.1093/brain/aww096
- Publication Year :
- 2016
- Publisher :
- Oxford University Press, 2016.
-
Abstract
- SEE DREIER DOI 101093/AWW112 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: For many decades a breakdown of the blood-brain barrier has been postulated to occur in migraine. Hypothetically this would facilitate access of medications, such as dihydroergotamine or triptans, to the brain despite physical properties otherwise restricting their entry. We studied the permeability of the blood-brain barrier in six migraineurs and six control subjects at rest and during acute glyceryl trinitrate-induced migraine attacks using positron emission tomography with the novel radioligand (11)C-dihydroergotamine, which is chemically identical to pharmacologically active dihydroergotamine. The influx rate constant Ki, average dynamic image and time activity curve were assessed using arterial blood sampling and served as measures for receptor binding and thus blood-brain barrier penetration. At rest, there was binding of (11)C-dihydroergotamine in the choroid plexus, pituitary gland, and venous sinuses as expected from the pharmacology of dihydroergotamine. However, there was no binding to the brain parenchyma, including the hippocampus, the area with the highest density of the highest-affinity dihydroergotamine receptors, and the raphe nuclei, a postulated brainstem site of action during migraine, suggesting that dihydroergotamine is not able to cross the blood-brain barrier. This binding pattern was identical in migraineurs during glyceryl trinitrate-induced migraine attacks as well as in matched control subjects. We conclude that (11)C-dihydroergotamine is unable to cross the blood-brain barrier interictally or ictally demonstrating that the blood-brain barrier remains tight for dihydroergotamine during acute glyceryl trinitrate-induced migraine attacks.
- Subjects :
- 0301 basic medicine
Adult
Male
Migraine Disorders
Vasodilator Agents
610 Medicine & health
Triptans
Pharmacology
Blood–brain barrier
Dihydroergotamine
03 medical and health sciences
Nitroglycerin
0302 clinical medicine
medicine
Radioligand
Humans
Vasoconstrictor Agents
Ictal
business.industry
Middle Aged
medicine.disease
3. Good health
030104 developmental biology
medicine.anatomical_structure
Migraine
Blood-Brain Barrier
Anesthesia
Positron-Emission Tomography
Choroid plexus
Female
Neurology (clinical)
Raphe nuclei
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Schankin, Christoph; Maniyar, Farooq H; Seo, Youngho; Kori, Shashidar; Eller, Michael; Chou, Denise E; Blecha, Joseph; Murphy, Stephanie T; Hawkins, Randall A; Sprenger, Till; VanBrocklin, Henry F; Goadsby, Peter J (2016). Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine. Brain, 139(Pt 7), pp. 1994-2001. Oxford University Press 10.1093/brain/aww096 <http://dx.doi.org/10.1093/brain/aww096>
- Accession number :
- edsair.doi.dedup.....0eed7fa579a935700529351263f1a7de