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Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
- Source :
- Scientific Reports, Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging. However, this hypothesis remains to be fully tested. Here, we studied 6 young and 12 old Chinese rhesus macaques (ChRM) over the course of three months after simian immunodeficiency virus (SIV) SIVmac239 infection. Old ChRM showed a higher risk of accelerated AIDS development than did young macaques, owing to rapidly elevated plasma viral loads and decreased levels of CD4+ T cells. The low frequency of naïve CD4+ T cells before infection was strongly predictive of an increased disease progression, whereas the severe depletion of CD4+ T cells and the rapid proliferation of naïve lymphocytes accelerated the exhaustion of naïve lymphocytes in old ChRM. Moreover, in old ChRM, a robust innate host response with defective regulation was associated with a compensation for naïve T cell depletion and a high level of immune activation. Therefore, we suggest that immunosenescence plays an important role in the accelerated AIDS progression in elderly individuals and that SIV-infected old ChRM may be a favorable model for studying AIDS pathogenesis and researching therapies for elderly AIDS patients.
- Subjects :
- CD4-Positive T-Lymphocytes
Male
0301 basic medicine
Aging
Naive T cell
Immunosenescence
Science
Simian Acquired Immunodeficiency Syndrome
medicine.disease_cause
Article
Pathogenesis
03 medical and health sciences
Acquired immunodeficiency syndrome (AIDS)
Immunity
medicine
Animals
Multidisciplinary
business.industry
Disease progression
Viral Load
Simian immunodeficiency virus
medicine.disease
Macaca mulatta
Virology
Immunity, Innate
030104 developmental biology
Immunology
Disease Progression
Medicine
Simian Immunodeficiency Virus
business
Viral load
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....0ef6ae2c2a3f543e9cd4c232207a0ec7
- Full Text :
- https://doi.org/10.1038/s41598-017-00084-0