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Performing skin microbiome research: a method to the madness
- Source :
- J. Invest. Dermatol. 137, 561-568 (2017)
- Publication Year :
- 2017
-
Abstract
- Growing interest in microbial contributions to human health and disease has increasingly led investigators to examine the microbiome in both healthy skin and cutaneous disorders, including acne, psoriasis and atopic dermatitis. The need for common language, effective study design, and validated methods are critical for high-quality, standardized research. Features, unique to skin, pose particular challenges when conducting microbiome research. This review discusses microbiome research standards and highlights important factors to consider, including clinical study design, skin sampling, sample processing, DNA sequencing, control inclusion, and data analysis.
- Subjects :
- 0301 basic medicine
Research design
medicine.medical_specialty
Sample processing
Dermatology
Disease
OTU, operational taxonomic unit
rRNA, ribosomal RNA
V, variable
Biology
Bioinformatics
Skin Diseases
Biochemistry
Article
Dermatitis, Atopic
03 medical and health sciences
Psoriasis
Acne Vulgaris
medicine
Humans
Microbiome
ddc:610
Intensive care medicine
Molecular Biology
Acne
Skin
Clinical Trials as Topic
Microbiota
Clinical study design
Sequence Analysis, DNA
Cell Biology
Atopic dermatitis
medicine.disease
030104 developmental biology
Research Design
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- J. Invest. Dermatol. 137, 561-568 (2017)
- Accession number :
- edsair.doi.dedup.....0f04720cc44bc97c216e9bbffbb16d72