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Post‐traumatic stress disorder in Stevens–Johnson syndrome and toxic epidermal necrolysis: prevalence and risk factors. A prospective study of 31 patients
- Source :
- British Journal of Dermatology, British Journal of Dermatology, Wiley, 2019, 180 (5), pp.1206-1213. ⟨10.1111/bjd.17267⟩
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- International audience; Background: Epidermal necrolysis is a rare and severe cutaneous adverse reaction to drugs with long-term somatic consequences and potentially underrecognized psychological complications.Objectives: To assess the prevalence and risk factors of post-traumatic stress disorder (PTSD) in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in a population of adults undergoing psychiatric evaluation.Methods: In this prospective study, we included adult patients admitted at the acute phase of SJS/TEN to our dermatology department from June 2009 to February 2013. The main objective was to assess the prevalence of PTSD at 6 months after the acute disease phase, defined by a PTSD Checklist score > 44. Secondary objectives were to investigate risk factors of PTSD in the medical history of patients and characteristics of the disease at the acute phase by the Peritraumatic Dissociative Experience Questionnaire (PDEQ) and Peritraumatic Distress Inventory (PDI) and the degree of impairment on the Sheehan Disability Scale.Results: We initially included 32 of 80 patients admitted during the study period. At 6 months, seven of 30 still followed up had a PTSD Checklist score > 44, suggesting a PTSD prevalence of 23%; 23 (77%) patients had a hydroxyzine prescription at the acute phase. The main risk factors associated with PTSD at 6 months were psychological results at the acute phase.Conclusions: Despite frequent prescription of hydroxyzine at the acute phase, almost one-quarter of patients with SJS/TEN had PTSD at 6 months. A systematic psychiatric evaluation should be offered regularly for at least 1 year after the acute disease phase.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
Psychometrics
Population
Dermatology
Severity of Illness Index
Stress Disorders, Post-Traumatic
Young Adult
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Risk Factors
Severity of illness
Prevalence
medicine
Humans
Medical history
Prospective Studies
Survivors
education
Prospective cohort study
Adverse effect
Aged
Retrospective Studies
education.field_of_study
business.industry
Traumatic stress
Retrospective cohort study
[SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology
Middle Aged
medicine.disease
Toxic epidermal necrolysis
Hydroxyzine
Stevens-Johnson Syndrome
Acute Disease
Histamine H1 Antagonists
Female
business
[SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Follow-Up Studies
Subjects
Details
- ISSN :
- 13652133 and 00070963
- Volume :
- 180
- Database :
- OpenAIRE
- Journal :
- British Journal of Dermatology
- Accession number :
- edsair.doi.dedup.....0f07ae403656c7451ebc95feb409a94c