Sleep duration and napping in relation to colorectal and gastric cancer in the MCC‑Spain study

Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case–control study (2008–2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal ( OR≥9 hours: 1.59; 95%CI 1.30–1.94) and gastric cancer ( OR≥9 hours: 1.95; 1.37–2.76); short sleep was associated with increased odds of gastric cancer ( OR≤5 hours: 1.32; 0.93–1.88). Frequent and long daytime naps increased the odds of colorectal ( OR6–7 naps/week, ≥30 min: 1.32; 1.14–1.54) and gastric cancer ( OR6–7 naps/week, ≥30 min: 1.56; 1.21–2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.
Catalan Government DURSI 2009SGR1489,RYC-2017-01892
Catalan Institute of Oncology
Centro de Investigacion Biomedica en Red: Epidemiologia y Salud Publica
Consejería de Salud of the Junta de Andalucía 2009-S0143
FEDER funds/European Regional Develpment Fund
ICGC International Cancer Genome Consortium CLL
ICOBIOBANC
Red Temática de Investigación del Cáncer RD12/0036/0036
Spanish Association Against Cancer
Xarxa de Bancs de Tumors de Cata-lunya
Albert Einstein Cancer Center AECC
Ministerio de Ciencia, Innovación y Universidades MCIU
Eno Scientific Foundation
European Commission FOOD-CT-2006-036224-HIWATE EC
Generalitat de Catalunya 2017SGR723
Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR1085 AGAUR
Ministerio de Economía y Competitividad MINECO
Instituto de Salud Carlos III PI08/0533,PI08/1359,PI08/1770,PI11/00226,PI11/01403,PI11/01810,PI11/02213,PI12/00150,PI12/00265,PI12/00488,PI12/00715,PI12/01270 ISCIII
Ministerio de Ciencia e Innovación CEX2018-000806-S MICINN
European Social Fund ESF
European Regional Development Fund PI17/01280 ERDF
Conselleria de Sanitat Universal i Salut Pública 2010ACUP 00310,AP_061/10
Junta de Castilla y León LE22A10-2
Fundación Marqués de Valdecilla API 10/09 FMV