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Seroprevalence of Neutralizing Antibodies against Six Human Adenovirus Types Indicates the Low Level of Herd Immunity in Young Children from Guangzhou, China
- Source :
- Virologica Sinica
- Publication Year :
- 2020
- Publisher :
- Springer Singapore, 2020.
-
Abstract
- Human adenoviruses (HAdVs) commonly cause many diseases such as respiratory diseases, gastroenteritis, cystitis worldwide. HAdV-3, -7, -4 and emergent HAdV-55 and HAdV-14 are the most important types causing severe respiratory diseases. There is no effective drug available for clinical treatment, and no vaccine available for the general population. Therefore, it is important to investigate the seroprevalence against HAdV for developing novel vaccines and vectors. In this study, we investigated the seroprevalence and titer levels of neutralizing antibodies (NAb) against HAdV-3, -4, -7, -14, -55, and -11 in total 278 healthy populations between 0 months and 49 years of age (228 children and 50 adults) from Guangzhou. In children under the age of 18 years, the seropositive rates were significantly increased against HAdV-3 at 12.07%, 33.96%, and 64.29% and against HAdV-7 at 0%, 18.87%, and 19.05% in age groups of 1–2, 3–5, and 6–17 years, respectively. The seroprevalence was very low (0% ~ 8.1%) for all other four types. In adults aged between 18 and 49 years, HAdV-3, -4, and -7 (> 50.00%) were the most common types, followed by HAdV-14 (38.00%), -55 (34.00%), and -11 (24.00%). Adults tended to have high NAb titers against HAdV-4 and -55. HAdV-55-seropositive donors tended to be HAdV-11- and HAdV-14-seropositive. These results indicated the low level of herd immunity against all six HAdV types in young children, and HAdV-14, -55, -11 in adults from Guangzhou City. Our findings demonstrate the importance of monitoring HAdV types and developing vaccines against HAdV for children and adults.
- Subjects :
- 0301 basic medicine
Adult
Immunity, Herd
medicine.medical_specialty
China
Adolescent
030106 microbiology
Immunology
Population
Seroprevalence
Antibodies, Viral
Herd immunity
Adenovirus Infections, Human
03 medical and health sciences
Young Adult
Medical microbiology
Seroepidemiologic Studies
Virology
Medicine
Humans
Vector (molecular biology)
education
Child
education.field_of_study
Neutralizing antibodies (NAb)
biology
business.industry
Adenoviruses, Human
Vaccination
Acute respiratory disease
virus diseases
Middle Aged
Antibodies, Neutralizing
eye diseases
Titer
Human adenovirus (HAdV)
030104 developmental biology
Child, Preschool
biology.protein
Molecular Medicine
Vector
Antibody
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 1995820X and 16740769
- Database :
- OpenAIRE
- Journal :
- Virologica Sinica
- Accession number :
- edsair.doi.dedup.....0f29a72c0f52f266e19e54e0f7f47c36