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Fatigue and herpesvirus latency in women newly diagnosed with breast cancer
Fatigue and herpesvirus latency in women newly diagnosed with breast cancer
- Source :
- Brain, Behavior, and Immunity. 26:394-400
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Fatigue is a notable clinical problem in cancer survivors, and understanding its pathophysiology is important. The current study sought to determine biomarkers of fatigue that exist before cancer treatment. Relationships between the expression of latent Epstein–Barr virus (EBV) and cytomegalovirus (CMV) and fatigue were examined in 158 women newly diagnosed with breast cancer or awaiting a positive diagnostic result. Higher CMV antibody titers, but not EBV antibody titers, were associated with a greater likelihood of being fatigued. Associations between fatigue and higher CMV antibody titers remained after controlling for alcohol use, smoking, comorbidities, depressive symptoms, age, BMI, cancer stage, and sleep problems. More sleep problems and higher levels of depressive symptoms were also associated with a greater likelihood of being fatigued. CMV antibody titers, but not EBV antibody titers, were associated with higher levels of C-reactive protein (CRP), but CRP was not associated with fatigue. When the cellular immune system is compromised, reactivation of latent herpesviruses may fuel chronic inflammatory responses. Prior work has suggested that fatigue may be related to inflammation and its associated sickness behaviors; accordingly, our findings may be tapping into this same physiological substrate.
- Subjects :
- Adult
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Immunology
Cytomegalovirus
Breast Neoplasms
Antibodies, Viral
medicine.disease_cause
Article
Behavioral Neuroscience
Breast cancer
Immune system
Sleep Initiation and Maintenance Disorders
Humans
Medicine
Epstein–Barr virus infection
Fatigue
Depression (differential diagnoses)
Aged
biology
Depression
Endocrine and Autonomic Systems
business.industry
C-reactive protein
Cancer
Middle Aged
medicine.disease
C-Reactive Protein
Cytomegalovirus Infections
biology.protein
Female
Antibody
business
Subjects
Details
- ISSN :
- 08891591
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Brain, Behavior, and Immunity
- Accession number :
- edsair.doi.dedup.....0f2f62427b26168aa73ab41cf7e96cb8
- Full Text :
- https://doi.org/10.1016/j.bbi.2011.09.014