In Vitro Activity of TP-271 against Mycobacterium abscessus, Mycobacterium fortuitum, and Nocardia Species

The in vitro activities of TP-271, a novel fluorocycline antimicrobial, against 22 isolates of Mycobacterium abscessus , 22 isolates of Mycobacterium fortuitum , and 19 isolates of Nocardia spp. were studied by a microtiter broth dilution method. The MIC 90 s for M. abscessus , M. fortuitum , and Nocardia spp. were 0.5 μg/ml, 0.03 μg/ml, and 8 μg/ml, respectively. TP-271 was significantly more active than the respective control drug in virtually all tests.