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Mitogenomic analyses propose positive selection in mitochondrial genes for high-altitude adaptation in galliform birds
- Source :
- Mitochondrion. 18:70-75
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Galliform birds inhabit very diverse habitats, including plateaus that are above 3000 m in altitude. At high altitude, lower temperature and hypoxia are two important factors influencing survival. Mitochondria, as the ultimate oxygen transductor, play an important role in aerobic respiration through oxidative phosphorylation (OXPHOS). We analyzed the mitochondrial genomes of six high-altitude phasianidae birds and sixteen low-altitude relatives in an attempt to determine the role of mitochondrial genes in high-altitude adaptation. We reconstructed the phylogenetic relationships of these phasianidae birds and relatives and found at least four lineages that independently occupied this high-altitude habitat. Selective analyses revealed significant evidence for positive selection in the genes ND2, ND4, and ATP6 in three of the high-altitude lineages. This result strongly suggests that adaptive evolution of mitochondrial genes played a critical role during the independent acclimatization to high altitude by galliform birds.
- Subjects :
- Mitochondrial DNA
Adaptation, Biological
Sequence Homology
Mitochondrion
DNA, Mitochondrial
Genome
Acclimatization
Animals
Galliformes
Selection, Genetic
Molecular Biology
Gene
Phylogeny
biology
Phylogenetic tree
Ecology
Altitude
NADH Dehydrogenase
Cell Biology
Mitochondrial Proton-Translocating ATPases
Effects of high altitude on humans
biology.organism_classification
Biological Evolution
Phasianidae
Genes, Mitochondrial
Evolutionary biology
Genome, Mitochondrial
Molecular Medicine
Subjects
Details
- ISSN :
- 15677249
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Mitochondrion
- Accession number :
- edsair.doi.dedup.....0f3de1d2702e07bfbef258e990836018