Back to Search
Start Over
Inhibition of miR-93 promotes interferon effector signaling to suppress influenza A infection by upregulating JAK1
- Source :
- International Immunopharmacology. 86:106754
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Type I interferons play a critical role in host defense against influenza virus infection. Interferon cascade induces the expression of interferon-stimulated genes then subsequently promotes antiviral immune responses. The microRNAs are important regulators of innate immunity, but microRNAs-mediated regulation of interferon cascade during influenza infection remains to be fully identified. Here we found influenza A virus (IAV) infection significantly inhibited miR-93 expression in alveolar epithelial type II cells through RIG-I/JNK pathway. IAV-induced downregulation of miR-93 was found to upregulate JAK1, the target of miR-93, and then feedback promote antiviral innate response by facilitating IFN effector signaling. Importantly, in vivo administration of miR-93 antagomiR markedly suppressed IAV infection, protecting mice form IAVs -associated death. Hence, the inducible downregulation of miR-93 feedback suppress IAV infection by strengthening IFN-JAK-STAT pathway via JAK1 upregulation, and in vivo inhibition of miR-93 bears considerable therapeutic potential for suppressing IAV infection.
- Subjects :
- Male
0301 basic medicine
MAP Kinase Kinase 4
Immunology
Receptors, Cell Surface
Biology
medicine.disease_cause
Virus
Cell Line
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
Orthomyxoviridae Infections
Downregulation and upregulation
Interferon
Influenza, Human
Influenza A virus
medicine
Animals
Humans
Immunology and Allergy
Antagomir
Pharmacology
Innate immune system
Effector
Antagomirs
Janus Kinase 1
Mice, Inbred C57BL
MicroRNAs
030104 developmental biology
Gene Expression Regulation
chemistry
030220 oncology & carcinogenesis
Cancer research
Interferons
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 15675769
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- International Immunopharmacology
- Accession number :
- edsair.doi.dedup.....0f42c00038a3166903ae625ce8ccbbea