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Synthesis of a MUC1-glycopeptide-BSA conjugate vaccine bearing the 3'-deoxy-3'-fluoro-Thomsen-Friedenreich antigen
- Source :
- Chemical communications (Cambridge, England). 47(35)
- Publication Year :
- 2011
-
Abstract
- A novel MUC1-glycopeptide–BSA conjugate vaccine with a specifically fluorinated Thomsen–Friedenreich antigen side chain at Thr6 was prepared. Preliminary immunological experiments reveal specific binding of the tumor-associated glycopeptide antigen analog by anti-MUC1-mouse antibodies.
- Subjects :
- digestive system
Catalysis
Mice
Antigen
Conjugate vaccine
Materials Chemistry
Animals
Antigens, Tumor-Associated, Carbohydrate
skin and connective tissue diseases
neoplasms
MUC1
Vaccines, Conjugate
biology
Thomsen-Friedenreich Antigen
Chemistry
Mucin-1
Metals and Alloys
Glycopeptides
Serum Albumin, Bovine
General Chemistry
Molecular biology
biological factors
digestive system diseases
Glycopeptide
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
biology.protein
Cattle
Antibody
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 47
- Issue :
- 35
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....0f54ddd3fc272fb1b8ab863432adf18e