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The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma
- Source :
- Antioxidantsredox signaling. 30(10)
- Publication Year :
- 2018
-
Abstract
- Peroxiredoxin 4 (PRDX4) is a member of the peroxiredoxin family of antioxidant enzymes. Previously, we reported that PRDX4 can restrain the initiation and progression of nonalcoholic steatohepatitis by reducing local and systemic reactive oxygen species (ROS) levels. Oxidative stress is recognized as a key factor in hepatocarcinogenesis, and a high ROS level has also been found in hepatocellular carcinoma (HCC). Here, our aim is to investigate roles of PRDX4 in the initiation and progression of HCC.In this study, for hepatocarcinogenesis, wild-type (WT), PRDX4 knockout (PRDX4
- Subjects :
- 0301 basic medicine
Male
Antioxidant
Physiology
medicine.medical_treatment
Clinical Biochemistry
Apoptosis
medicine.disease_cause
Biochemistry
Cohort Studies
Gene Knockout Techniques
Mice
Diethylnitrosamine
General Environmental Science
chemistry.chemical_classification
Peroxiredoxin-4
Liver Neoplasms
food and beverages
Hep G2 Cells
respiratory system
Gene Expression Regulation, Neoplastic
Hepatocellular carcinoma
Disease Progression
Female
medicine.symptom
Programmed cell death
Carcinoma, Hepatocellular
Down-Regulation
Inflammation
Mice, Transgenic
03 medical and health sciences
Cell Line, Tumor
medicine
Animals
Humans
Molecular Biology
Aged
Cell Proliferation
030102 biochemistry & molecular biology
business.industry
fungi
Cell Biology
Peroxiredoxins
medicine.disease
Survival Analysis
Disease Models, Animal
030104 developmental biology
Enzyme
chemistry
Cancer research
General Earth and Planetary Sciences
Peroxiredoxin
business
Reactive Oxygen Species
Oxidative stress
Subjects
Details
- ISSN :
- 15577716
- Volume :
- 30
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Antioxidantsredox signaling
- Accession number :
- edsair.doi.dedup.....0f6d357d779478425cb70c054231934d