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Anti-Inflammatory Effects of Dietary Plant Stanol Supplementation Are Largely Dependent on the Intake of Cholesterol in a Mouse Model of Metabolic Inflammation
- Source :
- Biomedicines, Biomedicines, Vol 9, Iss 518, p 518 (2021), Biomedicines, 9(5):518. MDPI AG, Volume 9, Issue 5
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- The prevalence of metabolic disorders characterized by chronic inflammation has been on a sharp rise for decades. As such, tools that address metabolic and inflammatory dysregulation are of great importance. Plant stanols are well-known for reducing intestinal cholesterol absorption and may also have direct anti-inflammatory effects. In this study, our aim was to investigate to what extent the benefits of dietary plant stanol supplementation depend on dietary cholesterol intake in an experimental mouse model for cholesterol-induced metabolic inflammation. Here, we used Ldlr−/− mice transplanted with Npc1nih-derived bone marrow, featuring feature bone marrow-derived immune cells characterized by chronic inflammation induced by lysosomal lipid accumulation. Npc1nih- and Npc1wt-transplanted mice were placed on either a high fat, high cholesterol (HFC) or on a chow diet low in cholesterol, with or without 2% plant stanols supplementation. At the end of the study, the metabolic and inflammatory status of the mice was analyzed. Plant stanol supplementation to the HFC diet reduced liver cholesterol levels and improved lipid metabolism and liver inflammation, particularly in Npc1nih-tp mice. In contrast, plant stanol supplementation to the chow diet did not significantly improve the aforementioned parameters, though similar reductive trends to those in the HFC diet setting were observed regarding liver cholesterol accumulation and liver inflammatory markers. The effects of dietary plant stanol supplementation on dietary cholesterol-induced inflammation are largely dependent on dietary cholesterol intake. Future research should verify whether other models of metabolic inflammation exhibit similar stanol-related effects on inflammation.
- Subjects :
- 0301 basic medicine
plant stanols
medicine.medical_specialty
SYMPTOMS
medicine.drug_class
QH301-705.5
Medicine (miscellaneous)
Inflammation
030204 cardiovascular system & hematology
General Biochemistry, Genetics and Molecular Biology
High cholesterol
Anti-inflammatory
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
Internal medicine
medicine
Biology (General)
hepatic inflammation
business.industry
Cholesterol
cholesterol
Lipid metabolism
medicine.disease
030104 developmental biology
Endocrinology
medicine.anatomical_structure
chemistry
Intestinal cholesterol absorption
lipids (amino acids, peptides, and proteins)
Bone marrow
medicine.symptom
business
diet
Subjects
Details
- Language :
- English
- ISSN :
- 22279059
- Volume :
- 9
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Biomedicines
- Accession number :
- edsair.doi.dedup.....0f7965a10d74167faf05c3b655db0b18