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Risk of diabetes mellitus in patients with prostate cancer receiving injection therapy: A nationwide population-based propensity score-matched study
- Source :
- International journal of clinical practiceREFERENCES. 75(9)
- Publication Year :
- 2020
-
Abstract
- Objectives We aimed to investigate whether the risk of diabetes mellitus (DM) is heightened in patients with prostate cancer receiving injection therapy. Methods Men diagnosed with prostate cancer between 2000 and 2012 were included in the case cohort, and men without prostate cancer were included as controls. Each patient with prostate cancer was matched with a control patient with the same index year, demographic variables and comorbidities, and comparisons were made using propensity score matching. The hazard ratio of DM was estimated using the Cox proportional hazards model. Results This cohort study consisted of 1213 patients with prostate cancer and 1213 control patients. The risk of DM in patients with prostate cancer was 1.60 times (95% CI = 1.12, 2.27) that of patients without prostate cancer. Compared with the controls, the hazard ratios of DM for patients with prostate cancer not receiving oral hormone therapy, patients with prostate cancer receiving oral hormone therapy, and patients with prostate cancer not receiving injection hormone therapy were 1.65 (95% CI = 1.01, 2.70), 1.57 (95% CI = 1.07, 2.70), and 1.94 (95% CI = 1.34, 2.81), respectively. The risk of DM in patients who received injection hormone therapy was 0.45 times (95% CI = 0.25, 0.82) that of patients who did not receive injection hormone therapy. Conclusion Patients with prostate cancer had an increased risk of DM compared with patients without prostate cancer. Patients with prostate cancer who received injection therapy had a lower risk of DM compared with those who did not.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
030204 cardiovascular system & hematology
Lower risk
Cohort Studies
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Risk Factors
Internal medicine
Diabetes Mellitus
Medicine
Humans
030212 general & internal medicine
Propensity Score
Proportional Hazards Models
Retrospective Studies
business.industry
Proportional hazards model
Hazard ratio
Prostatic Neoplasms
General Medicine
medicine.disease
Cohort
Propensity score matching
Hormone therapy
business
Cohort study
Subjects
Details
- ISSN :
- 17421241
- Volume :
- 75
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- International journal of clinical practiceREFERENCES
- Accession number :
- edsair.doi.dedup.....0f7971f44b0aecde16c12bda1d09cd86