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Interpreting challenge data from early phase malaria blood stage vaccine trials
- Source :
- Expert Review of Vaccines. 17:189-196
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- Introduction: As the quest for an effective blood stage malaria vaccine continues, there is increasing reliance on the use of controlled human malaria infections (CHMI) in non-endemic settings to test vaccine efficacy at the earliest possible time. This is seen as a way to accelerate vaccine research and quickly eliminate candidates with poor efficacy.Areas covered: The data from these studies need to be carefully examined and interpreted in light of the very different roles that antibody and cellular immunity play in protection and within the context of the distinct clinical sensitivities of volunteers living in malaria-non-endemic countries compared to those living in endemic countries. With current strategies, it is likely that vaccines with protective immunological ‘signatures’ will be missed and potentially good candidates discarded.Expert commentary: Efficacy data from early phase vaccine trials in non-endemic countries should not be used to decide whether or not to proceed to vaccine trials...
- Subjects :
- 0301 basic medicine
Vaccine research
Cellular immunity
medicine.medical_specialty
Time Factors
Research Subjects
Immunology
Blood stage malaria
Context (language use)
03 medical and health sciences
0302 clinical medicine
Malaria Vaccines
Drug Discovery
medicine
Humans
030212 general & internal medicine
Intensive care medicine
Pharmacology
Clinical Trials as Topic
Immunity, Cellular
business.industry
medicine.disease
Vaccine efficacy
Malaria
Blood stage
030104 developmental biology
Drug Design
Molecular Medicine
Early phase
business
Subjects
Details
- ISSN :
- 17448395 and 14760584
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Expert Review of Vaccines
- Accession number :
- edsair.doi.dedup.....0f918a7c15ceac9c99da2d69af4532a6