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Anti-renin T cells trigger normal B cells to produce anti-renin antibodies and normalize blood pressure in spontaneously hypertensive rats
- Source :
- International Immunology. 5:1569-1576
- Publication Year :
- 1993
- Publisher :
- Oxford University Press (OUP), 1993.
-
Abstract
- Spontaneously hypertensive (SH) rats immunized with mouse renin produce anti-renin antibodies, responsible for down-modulation of blood pressure, associated with an infiltration of kidneys by mononuclear cells. In this work, anti-renin T cells from SH rats immunized with renin have been stimulated in vitro, and we have studied in vitro and in vivo their effect on anti-renin antibody production by normal syngeneic B cells. We show that, in vitro, renin-activated T cells induce a renin-specific antibody response without addition of exogenous renin. Anti-renin T cells injected into naive SH rats trigger normal B cells to secrete high amounts of monospecific anti-renin IgG antibodies as early as day 5. These antibodies interfere with the homeostasis of the renin-angiotensin system leading to the normalization of blood pressure without any nephritis. These results show that anti-renin B cells are either not tolerant per se or in a reversible state of anergy. Our results also suggest that anti-renin B cells constitutively express renin-derived peptides in such a way that they may be stimulated by activated anti-renin T cells; these cells express IL-4 mRNA indicating that IL-4 could play a role in the differentiation of B cells.
- Subjects :
- Male
medicine.medical_specialty
Adoptive cell transfer
Ovalbumin
T-Lymphocytes
Molecular Sequence Data
Immunology
Cell Communication
Biology
Lymphocyte Activation
Interferon-gamma
Immune system
Rats, Inbred SHR
Internal medicine
Renin
Renin–angiotensin system
medicine
Animals
Immunology and Allergy
Cells, Cultured
Interleukin 4
B-Lymphocytes
Base Sequence
General Medicine
T lymphocyte
Flow Cytometry
In vitro
Rats
Endocrinology
Antibody Formation
Hypertension
biology.protein
Interleukin-2
Immunization
Antibody
Homeostasis
Subjects
Details
- ISSN :
- 14602377 and 09538178
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- International Immunology
- Accession number :
- edsair.doi.dedup.....0fb46c654bf39203acc0dd2e467e3948