Current Murine Models and New Developments in H3K27M Diffuse Midline Gliomas

Authors :: Desmond A. Brown
Anton Wohl
Liang Zhang
Timothy E. Peterson
David J. Daniels
Shiv K. Gupta
John P. Welby
Aditya Raghunathan
Tatiana Kaptzan
Source :: Frontiers in Oncology, Vol 9 (2019), Frontiers in Oncology
Publication Year :: 2019
Publisher :: Frontiers Media S.A., 2019.
Abstract: Diffuse Midline Gliomas with Histone 3-Lysine-27-Methionine (H3K27M) mutation constitute the majority of Diffuse Intrinsic Pontine Glioma (DIPG), which is the most aggressive form of pediatric glioma with a dire prognosis. DIPG are lethal tumors found in younger children with a median survival