Back to Search Start Over

Immediate histologic correlation in women with atypical squamous cells of undetermined significance cytology and positive high-risk HPV: A retrospective review of 6000 cases in a large academic women's hospital

Authors :
Tiannan Wang
Dinesh Pradhan
Chengquan Zhao
Jonee Matsko
Dayne Ashman
Huina Zhang
Source :
Cancer cytopathologyReferences. 128(11)
Publication Year :
2020

Abstract

BACKGROUND Previous studies of the histologic correlation in women who have atypical squamous cells of undetermined significance cytology (ASC-US) and are positive for high-risk human papillomavirus (hrHPV+) have predominantly utilized the Hybrid Capture 2 (HC2) test, whereas the use of other US Food and Drug Administration (FDA)-approved methods is relatively limited. METHODS Cases of ASC-US/hrHPV+ that were tested using HC2, Cervista, or Aptima were retrieved, and the immediate histologic correlations were analyzed. RESULTS Overall, 53.9% (n = 3238) of women with ASC-US/hrHPV+ had immediate histologic correlation. The detection rates for grade 1 cervical intraepithelial neoplasia (CIN1) were similar among the 3 methods (37.1%-41.8%), while the overall detection rates for grade 2 CIN or higher (CIN2+) were much lower (5.1%-9.0%). CIN2+ detection rates were similar among different age groups for HC2 testing, whereas for Cervista and Aptima testing, detection rates were highest in the youngest group (age

Details

ISSN :
19346638
Volume :
128
Issue :
11
Database :
OpenAIRE
Journal :
Cancer cytopathologyReferences
Accession number :
edsair.doi.dedup.....0fda1db744b657ea2e3d5dff12af1169