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The phylum Bryozoa: From biology to biomedical potential
- Source :
- Marine drugs, 18 (4, Marine drugs 18 (2020). doi:10.3390/md18040200, info:cnr-pdr/source/autori:Ciavatta, Maria Letizia; Lefranc, Florence; Vieira, Leandro M.; Kiss, Robert; Carbone, Marianna; van Otterlo, Willem A. L.; Lopanik, Nicole B.; Waeschenbach, Andrea/titolo:The Phylum Bryozoa: From Biology to Biomedical Potential/doi:10.3390%2Fmd18040200/rivista:Marine drugs/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:18, Marine Drugs, Vol 18, Iss 200, p 200 (2020), Marine Drugs
- Publication Year :
- 2020
-
Abstract
- Less than one percent of marine natural products characterized since 1963 have been obtained from the phylum Bryozoa which, therefore, still represents a huge reservoir for the discovery of bioactive metabolites with its ~6000 described species. The current review is designed to highlight how bryozoans use sophisticated chemical defenses against their numerous predators and competitors, and which can be harbored for medicinal uses. This review collates all currently available chemoecological data about bryozoans and lists potential applications/benefits for human health. The core of the current review relates to the potential of bryozoan metabolites in human diseases with particular attention to viral, brain, and parasitic diseases. It additionally weighs the pros and cons of total syntheses of some bryozoan metabolites versus the synthesis of non-natural analogues, and explores the hopes put into the development of biotechnological approaches to provide sustainable amounts of bryozoan metabolites without harming the natural environment.<br />SCOPUS: re.j<br />info:eu-repo/semantics/published
- Subjects :
- Antiparasitic
antiparasitic
Pharmaceutical Science
Review
Pharmacologie
anticancer
chemoecology
phylogeny
01 natural sciences
Bryozoa
03 medical and health sciences
Human health
Drug Discovery
Parasitic Diseases
Animals
Humans
Antiviral
Biology
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
lcsh:QH301-705.5
Phylogeny
030304 developmental biology
Biological Products
Brain Diseases
0303 health sciences
Chemoecology
Molecular Structure
biology
010405 organic chemistry
Phylum
Ecology
Bryozoan
bryozoan
biology.organism_classification
antiviral
0104 chemical sciences
Anticancer
lcsh:Biology (General)
Virus Diseases
Alzheimer
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Marine drugs, 18 (4, Marine drugs 18 (2020). doi:10.3390/md18040200, info:cnr-pdr/source/autori:Ciavatta, Maria Letizia; Lefranc, Florence; Vieira, Leandro M.; Kiss, Robert; Carbone, Marianna; van Otterlo, Willem A. L.; Lopanik, Nicole B.; Waeschenbach, Andrea/titolo:The Phylum Bryozoa: From Biology to Biomedical Potential/doi:10.3390%2Fmd18040200/rivista:Marine drugs/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:18, Marine Drugs, Vol 18, Iss 200, p 200 (2020), Marine Drugs
- Accession number :
- edsair.doi.dedup.....0fdde4bccb43d03a2aad46496659da84