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Supplementary Figures from Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma
- Publication Year :
- 2023
- Publisher :
- American Association for Cancer Research (AACR), 2023.
-
Abstract
- SF1: NDRG1 silencing upregulates GSK3β expression and cell growth signaling pathways; SF2: NDRG1 overexpression suppresses cell growth, GSK3β expression and cell growth signaling pathways; SF3: Effect of WT and Î"6 deletion mutant of NDRG1 on cell growth and cell growth signaling pathway in U251 cells; SF4: DIF-1 suppresses GBM cell growth accompanied with enhanced expression of NDRG1 and decreased expression of GSK3β; SF5: DIF-1 suppressed GBM cell growth by enhancing NDRG1 expression and decreasing GSK3β expression; SF6: Measurement of the DIF-1 concentration in mouse plasma and brain; SF7: DIF-1 suppresses tumor growth by U87MG cells in orthotopic therapeutic models; SF8: NDRG1 mRNA expression level does not predict overall survival of patients with GBM.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....0fe1c6ffc21ed0d969cc5c732215848b