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Handgrip Strength: Associations with Clinical Variables, Body Composition, and Bone Mineral Density in Adults with Cystic Fibrosis
- Source :
- Nutrients, Volume 13, Issue 11, Nutrients, Vol 13, Iss 4107, p 4107 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Background: Loss of fat-free mass (FFM) is associated with an increase in morbidity and mortality in cystic fibrosis (CF) patients. Handgrip strength (HGS) measures muscle function and may be associated with clinical parameters with prognostic value. Our objectives were to evaluate muscle strength through HGS in CF patients and to determine if there are any associations with respiratory clinical variables, FFM, and bone mineral density (BMD). Methods: A cross-sectional study conducted in clinically stable patients. We evaluated muscle function through HGS, respiratory function—forced expiratory volume in 1 s (FEV1) (%), forced vital capacity (FVC) (%), bronchorrhea, annual exacerbations, and body composition (FFM and FFM index, FFMI: fat-free mass in kg/height in m2) and Bone Mineral Density (BMD) through densitometry (DXA). Results: The study included 53 CF patients (58.5% females, mean age 28.3 ± 8.1, body mass index (BMI) 21.7 ± 3.4). The mean values for dynamometry were 40.2 ± 8.1 kg in males and 23.1 ± 7.0 kg in women, being 20.8% below the 10th percentile. Patients with lower muscle strength showed significantly more exacerbations and lower FEV1% and FVC%, as well as lower BMI, worse BMD (g/cm2), T-score, and Z-score. A significant and positive correlation was found between the mean and maximum dynamometry values and age, FVC%, BMI, FFMI, FFM (kg), and BMD. Conclusions: For adults with CF, HGS is a practical tool for assessment of health status. Low values reflect poor nutritional status and are associated with poor respiratory function, low fat-free mass and low bone mineral density.
- Subjects :
- Adult
Male
medicine.medical_specialty
Vital capacity
Percentile
Cystic Fibrosis
Nutritional Status
malnutrition
Gastroenterology
Article
Body Mass Index
Bronchorrhea
FEV1/FVC ratio
Absorptiometry, Photon
Bone Density
Predictive Value of Tests
Forced Expiratory Volume
Internal medicine
Humans
Medicine
TX341-641
Respiratory function
Jamar handgrip dynamometry
Bone mineral
handgrip strength
Nutrition and Dietetics
Hand Strength
Nutrition. Foods and food supply
business.industry
Prognosis
Bone Diseases, Metabolic
Cross-Sectional Studies
Nutrition Assessment
Adipose Tissue
nutritional assessment
Body Composition
Female
medicine.symptom
business
Densitometry
human activities
Body mass index
Food Science
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....100c4e2494d48c6fb66891a3d20aad52
- Full Text :
- https://doi.org/10.3390/nu13114107